This application is for renewal of the Training Program in Reproductive Biology in the Center for Studies in Reproduction (CSR) at the University of Maryland School of Medicine. This Program, established in 1973, provides multidisciplinary training in contemporary reproductive physiology/functional genomics with special emphasis on two areas: 1) neuroendocrinology and b) the hormonal control of developmental processes in reproductive tissues. The Program has grown to nine participants after the recent addition of two outstanding young NIH-funded reproductive endocrinologists to the faculty. Support for four pre-doctoral and four post-doctoral trainees is requested. Faculty members use a variety of whole animal, cellular, molecular, and genetic approaches to study: the regulation of angiogenesis; the role of growth factors in ovarian, uterine, and mammary gland tissue remodeling; effects of toxic agents on follicular development; developmental regulation of fetoplacental hormone synthesis in primates; K+ channel regulation of prolactin secretion; neuroendocrine regulation of LH and prolactin secretion; hormone regulation of breast and prostate cancer; and neuroendocrine regulation of reproductive behavior. Graduate students must complete a formal program of course work covering the principles of physiology, cell biology, and molecular biology and pass comprehensive qualifying exams to advance. They then undertake an independent research project in a sub-specialty of reproductive biology of their choice. Upon completion of their project they and must successfully defend the thesis to obtain the Ph.D. degree. Post-doctoral training is provided to individuals with the Ph.D. and/or M.D. degree with emphasis on the development of new concepts and technical skills and the acquisition of the experience required for advancement to an independent research career. Trainees are expected to play a major role in experimental design, implementation of methods, and data analysis and interpretation, and to publish their research in high-quality, peer-reviewed journals. The CSR, the participating Departments -- Physiology, Pharmacology, Neurobiology, and Epidemiology -- and the Graduate School provide an active program of seminars, symposia, and journal clubs and a stimulating environment for trainees to interact and develop. Trainees will enter the scientific community with a firm conceptual grasp of reproductive biology, familiarity with modem cellular, molecular, and genetic methodologies, and experience in in vivo and in vitro experimentation that will place them in a strong position in the rapidly-approaching post-genome era to play an important role in elucidating the function of the genes that determine reproductive function.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007170-22
Application #
6476620
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1979-07-01
Project End
2006-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
22
Fiscal Year
2002
Total Cost
$184,923
Indirect Cost
Name
University of Maryland Baltimore
Department
Physiology
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Rockwell, L Christie; Koos, Robert D (2009) Dexamethasone enhances fertility and preovulatory serum prolactin levels in eCG/hCG primed immature rats. J Reprod Dev 55:247-51
Greenfeld, Chuck R; Roby, Katherine F; Pepling, Melissa E et al. (2007) Tumor necrosis factor (TNF) receptor type 2 is an important mediator of TNF alpha function in the mouse ovary. Biol Reprod 76:224-31
Greenfeld, Chuck R; Babus, Janice K; Furth, Priscilla A et al. (2007) BAX is involved in regulating follicular growth, but is dispensable for follicle atresia in adult mouse ovaries. Reproduction 133:107-16
Greenfeld, Chuck R; Pepling, Melissa E; Babus, Janice K et al. (2007) BAX regulates follicular endowment in mice. Reproduction 133:865-76
Barnett, K R; Schilling, C; Greenfeld, C R et al. (2006) Ovarian follicle development and transgenic mouse models. Hum Reprod Update 12:537-55
Miller, Kimberly P; Gupta, Rupesh K; Greenfeld, Chuck R et al. (2005) Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathways. Toxicol Sci 88:213-21
Miller, Kimberly P; Borgeest, Christina; Greenfeld, Chuck et al. (2004) In utero effects of chemicals on reproductive tissues in females. Toxicol Appl Pharmacol 198:111-31
Greenfeld, Chuck; Flaws, Jodi A (2004) Renewed debate over postnatal oogenesis in the mammalian ovary. Bioessays 26:829-32
Pillai, Suresh B; Jones, Jenny M; Koos, Robert D (2002) Treatment of rats with 17beta-estradiol or relaxin rapidly inhibits uterine estrogen receptor beta1 and beta2 messenger ribonucleic acid levels. Biol Reprod 67:1919-26
Scarbrough, K; Jakubowski, M; Levin, N et al. (1994) The effect of time of day on levels of hypothalamic proopiomelanocortin primary transcript, processing intermediate and messenger ribonucleic acid in proestrous and estrous rats. Endocrinology 134:555-61

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