The proposed program is designed to furnish training for two graduate level predoctoral and four postdoctoral fellows per year in reproductive biology. Trainees are expected to go on to academic investigative careers in basic science or clinical departments. The training program has been operative for the past 15 years during which time 74 postdoctoral trainees (48 M.D., 8 M.D./Ph.D.,18/Ph.D.) and 22 graduate students have received training. Trainees are selected by a five member Steering Committee following formal application to the Reproductive Endocrinology Center and, in the case of predoctoral students, to the Biomedical Sciences Graduate Program. Graduate students will pursue a course of study leading to the Ph.D. degree in Biomedical Sciences. Postdoctoral training will be offered to Ph.D. candidates in related disciplines, and also to clinically trained scientists with M.D. degrees and prior specialty training in Obstetrics and Gynecology, Pediatrics or Internal Medicine. All entering fellows will be guided by a mentoring team to determine appropriate course work, and to initiate and follow research progress. M.D. fellows with no prior graduate education will spend the first year of a 3 year fellowship attending graduate level courses and performing research. All trainees will participate in the weekly Reproductive Biology Seminar Program and Research Workshop and will take the Molecular and Cellular Reproductive Biology Course. Research training will be provided by the 16 members of the Reproductive Endocrinology Center who hold faculty positions at UCSF School of Medicine and Dentistry in both basic science and clinical departments. Current research programs address important issues in reproductive biology including: sex determination, development of the reproductive tract, biology of the ovary and testes, endocrine regulation of normal and abnormal reproductive function and genetics of infertility. The Reproductive Endocrinology Center (REC) laboratories and offices consist of approximately 13,000 square feet on two floors of the Health Sciences Instruction and Research Building. In addition a primate facility, clinical research unit and transgenic barrier facility are available for studies. Histology, hormone measurement, protein separation and sequencing, and molecular biology cores also are available for training.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007263-19
Application #
6476629
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1983-07-01
Project End
2004-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
19
Fiscal Year
2002
Total Cost
$133,853
Indirect Cost
Name
University of California San Francisco
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Arora, Ripla; Abby, Emilie; Ross, Adam D J et al. (2016) Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci 129:2493-9
Herndon, Christopher N; Aghajanova, Lusine; Balayan, Shaina et al. (2016) Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis. Reprod Sci 23:1289-303
Arora, Ripla; Fries, Adam; Oelerich, Karina et al. (2016) Insights from imaging the implanting embryo and the uterine environment in three dimensions. Development 143:4749-4754
Feuer, Sky; Liu, Xiaowei; Donjacour, Annemarie et al. (2016) Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures. Reproduction :
Sousa Martins, Joao P; Liu, Xueqing; Oke, Ashwini et al. (2016) DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. J Cell Sci 129:1271-82
Cakmak, Hakan; Franciosi, Federica; Zamah, A Musa et al. (2016) Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells. Proc Natl Acad Sci U S A 113:2424-9
Chen, Joseph C; Hoffman, Jacquelyn R; Arora, Ripla et al. (2016) Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril 105:501-10.e1
Feuer, Sky; Rinaudo, Paolo (2016) From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies. Healthcare (Basel) 4:
Aghajanova, Lusine; Altmäe, Signe; Kasvandik, Sergo et al. (2016) Stanniocalcin-1 expression in normal human endometrium and dysregulation in endometriosis. Fertil Steril 106:681-691.e1
Bayless, Daniel W; Shah, Nirao M (2016) Genetic dissection of neural circuits underlying sexually dimorphic social behaviours. Philos Trans R Soc Lond B Biol Sci 371:20150109

Showing the most recent 10 out of 26 publications