During the past decade, basic scientists and clinicians have contributed greatly to our understanding of fundamental aspects of reproductive biology. In turn, this understanding has been applied toward the development of improved methods of contraception and for the diagnosis and treatment of disorders of the reproductive system, including infertility, cancer, congenital anomalies, precocious puberty, and problems associated with menopause. Continued success depends upon training a new generation of scientists who know the basic principles of modern biology and can apply modern research techniques to solve problems relevant to reproductive biology and medicine. This training program is designed to provide a program of study and research apprenticeship for postdoctoral scientists for a research career in the reproductive sciences and medicine. This program offers fellowships to eight postdoctoral candidates with either a doctoral degree (Ph.D.) in a basic science or a professional degree in the medical sciences (e.g., M.D.) that seek training in reproductive science and medicine. Periods of training will range from 1 to 3 years, depending on the previous experience of the trainees. Training opportunities are available from 21 faculty mentors, representing 10 departments at the University of Washington (in both the School of Medicine and the College of Arts and Sciences), the VA Puget Sound Health Care System, and the Fred Hutchinson Cancer Research Center. The disciplines represented include molecular and developmental biology, biophysics, molecular genetics, physiology, neuroendocrinology, behavioral endocrinology, and clinical reproductive endocrinology. The continuation of this successful program will offer a unique and diverse educational experience, comprising the whole organism, from molecule to behavior, and committed to communication and learning across disciplines.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007453-14
Application #
7231942
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1994-07-01
Project End
2009-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
14
Fiscal Year
2007
Total Cost
$161,184
Indirect Cost
Name
University of Washington
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Roth, Mara Y; Lin, K; Amory, J K et al. (2010) Serum LH correlates highly with intratesticular steroid levels in normal men. J Androl 31:138-45
DeFino, Mia C; Wacker, Jennifer L; Lyssand, John S et al. (2010) Differential regulation of GPR54 transcription by specificity protein-1 and partial estrogen response element in mouse pituitary cells. Biochem Biophys Res Commun 393:603-8
Burnett, Lindsey A; Blais, Edik M; Unadkat, Jashvant D et al. (2010) Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm. J Biol Chem 285:33662-70
Wacker, Jennifer L; Feller, David B; Tang, Xiao-Bo et al. (2008) Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. J Biol Chem 283:31068-78
DelloRusso, Christiana; Welcsh, Piri L; Wang, Weixin et al. (2007) Functional characterization of a novel BRCA1-null ovarian cancer cell line in response to ionizing radiation. Mol Cancer Res 5:35-45
Moore, Ignacio T; Bentley, George E; Wotus, Cheryl et al. (2006) Photoperiod-independent changes in immunoreactive brain gonadotropin-releasing hormone (GnRH) in a free-living, tropical bird. Brain Behav Evol 68:37-44
Ward, Ellen J; Berg, Celeste A (2005) Juxtaposition between two cell types is necessary for dorsal appendage tube formation. Mech Dev 122:241-55
Coviello, Andrea D; Matsumoto, Alvin M; Bremner, William J et al. (2005) Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression. J Clin Endocrinol Metab 90:2595-602
Coviello, Andrea D; Bremner, William J; Matsumoto, Alvin M et al. (2004) Intratesticular testosterone concentrations comparable with serum levels are not sufficient to maintain normal sperm production in men receiving a hormonal contraceptive regimen. J Androl 25:931-8
Schaeffer, Valerie; Althauser, Cassandra; Shcherbata, Halyna R et al. (2004) Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells. Curr Biol 14:630-6

Showing the most recent 10 out of 16 publications