EXCEED THE SPACE PROVIDED. The objective of this program is to prepare post-doctoral trainees to establish independent research careers in the areas of early pregnancy and embryonic development. The training program will consist of three elements; independent laboratory research, group seminars and other functions held jointly with the Center for Reproductive Sciences, and formal coursework in research ethics as well as subjects that will enhance the trainee's research expertise. The independent research will occur in a laboratory selected by the trainee from a group of ten scientists who are leaders in various aspects of reproductive and developmental biology. The members of this training group have well- established, NIH-funded programs and have trained more than 70 postdoctoral fellows. Areas of study include fertilization, peri-implantation development, trophoblast-uterine interactions, pituitary regulation of early pregnancy, the immunobiology of implantation and early pregnancy as well as regulationof gene expression duting development. The strength of this group is enhanced by collaboration among the members as evidenced by the record of jointpublications, grants, and students. This program will take advantage of an existing Center for Reproductive Sciences comprising 19 principal investigators and 58 additional staff and trainees to provide an enhanced training environment.The Center for Reproductive Sciences sponsors an active seminar program and hosts a regional conference in reproductive biology, which provide additional opportunities for trainees to present their work. The recruitment, selection and guidance of trainees will be coordinated through an Internal Advisory Committee, with input from all participating faculty and in consultation with an External Advisor, who will meet with the group once each year. Applicants who have been awarded a Ph.D. in one of the biological sciences, or a D.V.M. or M.D. and who demonstrate a commitment to research in reproductive biology will be considered for entry into the program. An emphasis will be placed on recruiting underrepresented minorities into the program. The records of the seven trainees selected during the first funding period are impressive. Six competed successfully for external funds (NRSA, Lalor and American Heart Association fellowships) and all three of the trainees who have completed their training have assumed academic faculty positions. The overall success of the program will ultimately be measured by the contributions of these trainees after they have established independent research programs. PERFORMANCE SITE ========================================Section End===========================================

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
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University of Kansas
Schools of Medicine
Kansas City
United States
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Perchellet, Antoine L; Jasti, Susmita; Petroff, Margaret G (2013) Maternal CD4ýýý and CD8ýýý T cell tolerance towards a fetal minor histocompatibility antigen in T cell receptor transgenic mice. Biol Reprod 89:102
Galvin-Burgess, Katherine E; Travis, Emily D; Pierson, Kelsey E et al. (2013) TGF-?-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium. Stem Cells 31:48-58
McGinnis, Lynda K; Hong, Xiaoman; Christenson, Lane K et al. (2011) Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes. Mol Reprod Dev 78:33-47
McGinnis, Lynda K; Carroll, David J; Kinsey, William H (2011) Protein tyrosine kinase signaling during oocyte maturation and fertilization. Mol Reprod Dev 78:831-45
Petroff, Margaret G; Perchellet, Antoine (2010) B7 family molecules as regulators of the maternal immune system in pregnancy. Am J Reprod Immunol 63:506-19
Duffy, Diane M; McGinnis, Lynda K; Vandevoort, Catherine A et al. (2010) Mammalian oocytes are targets for prostaglandin E2 (PGE2) action. Reprod Biol Endocrinol 8:131
Galvin, Katherine E; Travis, Emily D; Yee, Della et al. (2010) Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem 285:19747-56
Sharma, Dipika; Holets, Lesya; Zhang, Xiaoming et al. (2005) Role of Fyn kinase in signaling associated with epiboly during zebrafish development. Dev Biol 285:462-76
Petroff, Brian K; Croutch, Claire R; Hunter, Dora M et al. (2003) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) stimulates gonadotropin secretion in the immature female Sprague-Dawley rat through a pentobarbital- and estradiol-sensitive mechanism but does not alter gonadotropin-releasing hormone (GnRH) secretion by immorta Biol Reprod 68:2100-6
Rongish, B J; Kinsey, W H (2000) Transient nuclear localization of Fyn kinase during development in zebrafish. Anat Rec 260:115-23