The field of developmental biology has matured in recent years, largely through the integration of much of the biological sciences, including genetics, cell biology, embryology, physiology, molecular biology, biochemistry, and evolutionary biology. An understanding of development may well be fundamental to much of medicine and may ultimately contribute important information to many problems, ranging from congenital defects to senescence. The focus for developmental biology at the University of Minnesota is provided by the DBC, which is based in the Department of Genetics, Cell Biology, and Development (DGCB&D), an all-university department within both the School of Medicine and the College of Biological Sciences. However, the DBC embraces members from other departments within the University such as Neuroscience and Plant Biology. The DBC organizes a popular annual University of Minnesota Developmental Biology Symposium, runs a series of evening research seminars in developmental biology where graduate students and postdoctoral researchers present their work, and promotes interactions and collaborations among developmental biologists at the University of Minnesota. The trainers are all members of the Center and work in diverse areas of developmental biology using many different model organisms, including mice, chickens, zebrafish, Xenopus, Drosophila, C. elegans, Dictyostelium, and Arabidopsis, as well as humans. The principal graduate program for developmental biology trainees is the Molecular, Cellular, Developmental Biology, and Genetics (MCDB&G) graduate program. This program is built around strong core graduate courses in laboratory techniques, molecular biology, genetics, cell biology, developmental biology, literature analysis, and laboratory rotations in diverse systems. The trainers have strong research programs and strong records of commitment to graduate and postdoctoral training. Eight predoctoral trainees will be chosen for training grant support, largely from the pool of graduate students in MCDB&G, but possibly also from other graduate programs, such as neuroscience and biochemistry, molecular biology and biophysics. Trainees will be supported for one to three years, after they have begun their thesis work in the laboratories of the trainers. The training laboratories and core facilities are all well equipped.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007480-10
Application #
6884031
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Klein, Steven
Project Start
1995-09-29
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2007-04-30
Support Year
10
Fiscal Year
2005
Total Cost
$122,941
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Genetics
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Edelman, Theresa L B; McCulloch, Katherine A; Barr, Angela et al. (2016) Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing. G3 (Bethesda) 6:4077-4086
Ferrell, Patrick I; Hexum, Melinda K; Kopher, Ross A et al. (2014) Functional assessment of hematopoietic niche cells derived from human embryonic stem cells. Stem Cells Dev 23:1355-63
McCulloch, Katherine A; Rougvie, Ann E (2014) Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression. Proc Natl Acad Sci U S A 111:15450-5
Kang, Yuan-Lin; Yochem, John; Bell, Leslie et al. (2013) Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Mol Biol Cell 24:308-18
Berkseth, Matt; Ikegami, Kohta; Arur, Swathi et al. (2013) TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination. Proc Natl Acad Sci U S A 110:16033-8
Krentz, Anthony D; Murphy, Mark W; Zhang, Teng et al. (2013) Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol 377:67-78
Ran, Dan; Shia, Wei-Jong; Lo, Miao-Chia et al. (2013) RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood 121:2882-90
Zheng, Li; Saunders, Cosmo A; Sorensen, Erika B et al. (2013) Notch signaling from the endosome requires a conserved dileucine motif. Mol Biol Cell 24:297-307
Bluske, Krista K; Vue, Tou Yia; Kawakami, Yasuhiko et al. (2012) ?-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development 139:2692-702
Gibbens, Ying Y; Warren, James T; Gilbert, Lawrence I et al. (2011) Neuroendocrine regulation of Drosophila metamorphosis requires TGFbeta/Activin signaling. Development 138:2693-703

Showing the most recent 10 out of 29 publications