As one looks to a future in which interdisciplinary approaches in the biomedical sciences are crucial, it is important to identify strategies to help the next generation of scientists successfully navigate an increasingly complex research landscape and to forge new paths on the edges among disciplines. The field of organogenesis is one such complex and emerging discipline. The Center for Organogenesis at University of Michigan was formed in 1995 to unite basic, applied, and clinical scientists with a common goal: To understand the basic mechanisms by which organs and tissues are formed and maintained, and to use this knowledge to create long-lasting artificial organs, improved stem cell therapies, and effective organ transplantation systems that will correct acquired and genetic human diseases. The Training Program in Organogenesis, initiated nine years ago, is an integral part of the educational mission of the Center. Its goals are: a) to provide intellectual and technical training in the field of Organogenesis;and b) to promote interdisciplinary thinking by exposing trainees to research that crosses boundaries among the clinical, basic, and applied sciences. These goals are accomplished by encouraging a two-mentor structure for research training and requiring trainees to participate in several specific training activities: formal courses in Organogenesis, a Monthly Seminar series, Monthly Trainee Meeting, Journal Club, International Symposium, and the Organogenesis Students and Fellows Association (OFSA). Trainees also actively shape the training program, proposing new initiatives such as Bioartography, a novel combination of art, science, and public education and Crosstalk, a forum that improves communication between basic and clinical trainees and mentors thus provides an effective mechanism to recruit outstanding M.D. fellows to the training program. This competitive renewal requests support for six predoctoral and three postdoctoral training slots (one specifically targeted to an M.D. fellow). Trainees come primarily from the laboratories of the 33 listed mentors on the training program, all of whom are highly recognized scientists. Formal competitive applications, reviewed by a selection committee, are required for acceptance into the program. The program is monitored by several internal mechanisms and also by an External Advisor (Dr. Brigid Hogan, Duke University) to ensure its continued responsiveness to demands of an ever-changing research environment.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007505-14
Application #
7840421
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Javois, Lorette Claire
Project Start
1997-05-14
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
14
Fiscal Year
2010
Total Cost
$335,413
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Mills, Elizabeth A; Begay, Joel A; Fisher, Caitlyn et al. (2018) Impact of trial design and patient heterogeneity on the identification of clinically effective therapies for progressive MS. Mult Scler :1352458518800800
Bagchi, Devika P; Forss, Isabel; Mandrup, Susanne et al. (2018) SnapShot: Niche Determines Adipocyte Character II. Cell Metab 27:266-266.e1
Mills, Elizabeth A; Mao-Draayer, Yang (2018) Aging and lymphocyte changes by immunomodulatory therapies impact PML risk in multiple sclerosis patients. Mult Scler 24:1014-1022
Dame, Michael K; Attili, Durga; McClintock, Shannon D et al. (2018) Identification, isolation and characterization of human LGR5-positive colon adenoma cells. Development 145:
Mills, Elizabeth A; Mao-Draayer, Yang (2018) Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird's Eye View. Front Immunol 9:138
Li, Ziru; Hardij, Julie; Bagchi, Devika P et al. (2018) Development, regulation, metabolism and function of bone marrow adipose tissues. Bone 110:134-140
Trissal, Maria C; Wong, Terrence N; Yao, Juo-Chin et al. (2018) MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis. Cancer Res 78:3510-3521
Elsaeidi, Fairouz; Macpherson, Peter; Mills, Elizabeth A et al. (2018) Notch Suppression Collaborates with Ascl1 and Lin28 to Unleash a Regenerative Response in Fish Retina, But Not in Mice. J Neurosci 38:2246-2261
Bagchi, Devika P; Forss, Isabel; Mandrup, Susanne et al. (2018) SnapShot: Niche Determines Adipocyte Character I. Cell Metab 27:264-264.e1
Mills, Elizabeth A; Ogrodnik, Magdalena A; Plave, Andrew et al. (2018) Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis. Front Neurol 9:5

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