This is a competitive renewal for a pre- and postdoctoral training program in developmental biology. The proposed training program includes faculty from multiple schools and departments within the University and reflects a major expansion of developmental biology research and training at Penn. This expansion includes the formation of a Department of Cell and Developmental Biology and a graduate training program in developmental biology. The proposed pre- and postdoctoral training experience is centered primarily on training in laboratory research in basic mechanisms of embryonic development using a diversity of vertebrate, invertebrate, and plant organisms. It fosters the application of modern genetic, cellular, and molecular approaches to developmental studies. Research training areas include transcription and cell signaling mechanisms that control cell lineage determination, differentiation and migration, organogenesis, cellular senescence, morphogenesis, and pattern formation. Trainees also have opportunities for exposure to relevant clinical research in gene therapy, fetal surgery and genetic diseases of development. In preparation for their research training, predoctoral students receive formal instruction in an established curriculum of study, including lecture courses in developmental biology and advanced seminars on genetic, cellular, and molecular approaches to developmental mechanisms and disease. Pre- and postdoctoral students also participate in a developmental biology journal clubs, a seminar program, research discussion groups on selected topics, and an annual scientific symposium. Trainees present their research findings each semester at an informal meeting of trainees and trainers. The objectives of this training are to prepare trainees for careers as independent investigators in the field of developmental biology in academic and governmental institutions or in the biotechnology industry.
Ediger, Benjamin N; Lim, Hee-Woong; Juliana, Christine et al. (2017) LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ? cells. J Clin Invest 127:215-229 |
Monyak, R E; Emerson, D; Schoenfeld, B P et al. (2017) Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model. Mol Psychiatry 22:1140-1148 |
Hernandez-Fleming, Melissa; Rohrbach, Ethan W; Bashaw, Greg J (2017) Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins. Cell Rep 18:174-184 |
Zhang, Maomao; Skirkanich, Jennifer; Lampson, Michael A et al. (2017) Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition. Adv Exp Med Biol 953:441-487 |
Fleming, Michael S; Li, Jian J; Ramos, Daniel et al. (2016) A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. J Neurosci 36:10337-10355 |
Langdon, Yvette G; Fuentes, Ricardo; Zhang, Hong et al. (2016) Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis. Development 143:1016-28 |
Reid, Christine D; Steiner, Aaron B; Yaklichkin, Sergey et al. (2016) FoxH1 mediates a Grg4 and Smad2 dependent transcriptional switch in Nodal signaling during Xenopus mesoderm development. Dev Biol 414:34-44 |
Stein, Sarah J; Mack, Ethan A; Rome, Kelly S et al. (2016) Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. PLoS One 11:e0155408 |
Elliott, Ellen N; Sheaffer, Karyn L; Schug, Jonathan et al. (2015) Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Development 142:2163-72 |
Zhang, Maomao; Kothari, Priyanka; Lampson, Michael A (2015) Spindle assembly checkpoint acquisition at the mid-blastula transition. PLoS One 10:e0119285 |
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