Abstract

Description) This application requests support for a postdoctoral training program to develop researchers with expertise in both the biological basis and clinical manifestations of neurodevelopmental disorders, in order to enable them to better relate across disciplines and maximize potential for understanding the pathogenesis and treatment of these disorders. In the past, training program in behavioral science, neuroscience, and molecular genetics have led to dramatic gains in our understanding of the pathogenesis of neurodevelopmental disorders. The proposed training plan provides a variety of opportunities, including (1) mentored research training in specific methods, disorders, and underlying pathogenetic mechanisms; (2) a range of didactic experiences (such as courses, seminars, and lectures) that integrate the study of clinical disorders, normal developmental processes, mechanisms of disease and research methods; and, (3) clinical exposures to complement previous levels of clinical experience. Twelve to 15 Ph.D. or M.D. level trainees will participate in two to three year training over the five-year course of this program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD040127-05
Application #
6910794
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Oster-Granite, Mary Lou
Project Start
2001-05-15
Project End
2006-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
5
Fiscal Year
2005
Total Cost
$302,378
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Psychiatry
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

den Bakker, Hanna; Sidorov, Michael S; Fan, Zheng et al. (2018) Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study. Mol Autism 9:32
Sidorov, Michael S; Judson, Matthew C; Kim, Hyojin et al. (2018) Enhanced Operant Extinction and Prefrontal Excitability in a Mouse Model of Angelman Syndrome. J Neurosci 38:2671-2682
Bailey, Rachel M; Armao, Diane; Nagabhushan Kalburgi, Sahana et al. (2018) Development of Intrathecal AAV9 Gene Therapy for Giant Axonal Neuropathy. Mol Ther Methods Clin Dev 9:160-171
Lykken, Erik Allen; Shyng, Charles; Edwards, Reginald James et al. (2018) Recent progress and considerations for AAV gene therapies targeting the central nervous system. J Neurodev Disord 10:16
Greene, R K; Spanos, M; Alderman, C et al. (2018) The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder. J Neurodev Disord 10:12
Tuttle, Alexander H; Molinaro, Mark J; Jethwa, Jasmine F et al. (2018) A deep neural network to assess spontaneous pain from mouse facial expressions. Mol Pain 14:1744806918763658
Swanson, Meghan R; Wolff, Jason J; Shen, Mark D et al. (2018) Development of White Matter Circuitry in Infants With Fragile X Syndrome. JAMA Psychiatry 75:505-513
Swanson, Meghan R; Shen, Mark D; Wolff, Jason J et al. (2018) Naturalistic Language Recordings Reveal ""Hypervocal"" Infants at High Familial Risk for Autism. Child Dev 89:e60-e73
Emerson, Robert W; Adams, Chloe; Nishino, Tomoyuki et al. (2017) Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age. Sci Transl Med 9:
Gadalla, Kamal K E; Vudhironarit, Thishnapha; Hector, Ralph D et al. (2017) Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome. Mol Ther Methods Clin Dev 5:180-190

Showing the most recent 10 out of 137 publications