Pediatric Critical Care Medicine (PCCM) specialists are the front line in neurointensive care. They respond to crises in the pediatric intensive care unit, including resuscitation and treatment of children with severe traumatic brain injury (TBI) and in-hospital cardiopulmonary arrest (CA). They interact with child neurology, neurological surgery, and physical medicine and rehabilitation (PM&R) specialists in the continuum of care. Our unique postdoctoral program trains PCCM, child neurology, neurological surgery and PM&R fellows in basic and clinical research in neurointensive care and resuscitation, establishing a link between trainees and senior scientists. In this revised competitive renewal application, funds are requested to support a total of 5 positions each yr. The program is completing its 5th year and has filled every position with high-quality fellows. Three have submitted and two have acquired K awards, and 5 have acquired or are pursuing advanced degrees or certificates. They have published or in press 22 peer-reviewed papers, presented 62 abstracts, and won 8 awards. All graduates are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. A bench-to-bedside approach supported by federally funded studies by our faculty is used. We capitalize on the unique interaction between the Safar Center for Resuscitation Research and the PCCM, child neurology, neurological surgery, and PM&R training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Med. The director, co-director, and principal trainers (PTs) are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for trainee career development and hypothesis testing. We also integrate a curriculum in neurointensive care research. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions, and are trained in grantsmanship and research integrity. They acquire the thought process/tools to study future questions. Most training takes place in the labs of the PTs via a classical apprenticeship. A didactic program in pediatric neurointensive care/research methods is also included. Each fellow chooses a PT and an expert supervising subcommittee. Training is carried out in ~50,000 sq. ft. of fully equipped lab space. Administrative/technical staff is available, as is ample case material for clinical research. Affirmative action recruitment efforts are in place. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD040686-07
Application #
7227805
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Nicholson, Carol E
Project Start
2000-09-25
Project End
2011-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
7
Fiscal Year
2007
Total Cost
$249,669
Indirect Cost
Name
University of Pittsburgh
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Simon, Dennis W; Aneja, Rajesh K; Alexander, Henry et al. (2018) Minocycline Attenuates High Mobility Group Box 1 Translocation, Microglial Activation, and Thalamic Neurodegeneration after Traumatic Brain Injury in Post-Natal Day 17 Rats. J Neurotrauma 35:130-138
Alessi, Lauren J; Warmus, Holly R; Schaffner, Erin K et al. (2018) A Computable Definition of Sepsis Facilitates Screening and Performance Improvement Tracking. Pediatr Qual Saf 3:e067
Rosario, Bedda L; Horvat, Christopher M; Wisniewski, Stephen R et al. (2018) Presenting Characteristics Associated With Outcome in Children With Severe Traumatic Brain Injury: A Secondary Analysis From a Randomized, Controlled Trial of Therapeutic Hypothermia. Pediatr Crit Care Med 19:957-964
Jha, Ruchira Menka; Koleck, Theresa A; Puccio, Ava M et al. (2018) Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury. J Neurol Neurosurg Psychiatry 89:1152-1162
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Kim-Campbell, Nahmah; Gretchen, Catherine; Callaway, Clifton et al. (2017) Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass. Crit Care Med 45:e1123-e1130
Horvat, Christopher M; Clark, Robert S B (2017) Healthcare in the PICU May Be More Complicated Than We Thought-Who Knew? Pediatr Crit Care Med 18:1188-1189
Kochanek, Patrick M; Wallisch, Jessica S; Bay?r, Hülya et al. (2017) Pre-clinical models in pediatric traumatic brain injury-challenges and lessons learned. Childs Nerv Syst 33:1693-1701
Wallisch, Jessica S; Simon, Dennis W; Bay?r, Hülya et al. (2017) Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children. Neurocrit Care 27:44-50
Wallisch, Jessica S; Kochanek, Patrick M (2017) A ""Metamorphosis"" in Our Approach to Treatment Is Not Likely to Result From a Meta-Analysis of the Use of Therapeutic Hypothermia in Severe Traumatic Brain Injury. Crit Care Med 45:744-745

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