. The Endocrinology and Reproductive Physiology (ERP) Graduate Training Program is an interdisciplinary endocrine program with a longstanding focus on reproduction. As such, a major focus of its researchers relates to many focus areas of NICHD, ie reproductive biology and physiology, maternal health, and fetal health at the level of intrauterine programming and the origins of adult onset disease. This is achieved using multidisciplinary approaches from stem cells and cellular/molecular biology to comparative physiology of animals models to translational work in nonhuman primates and humans. Since 2014 we continue to show excellence in minority recruitment and training, and the further evolution of our training program continues with the addition of an advanced responsible conduct of research and professional development course. The outcomes for our trainees have been outstanding both in terms of publications and placement, and are fully detailed below. In the past three years we have seen an increase in human translational studies by multidisciplinary and interdisciplinary teams, the members of which are both MD and PhD. We have seen a dramatic increase in MD and MD/PhD trainers interested in reproduction as well of the study of adult outcome diseases (obesity, diabetes, hypertension) caused by prematurity/low birthweight and which themselves may lead to complicated pregnancy. We continue to train MD fellows in our Degree Fellowship Track within ERP. While MD candidates are not typically candidates for support under this T32 Predoctoral application, we wish the reviewers to be aware of the existence of this track within ERP as this impacts greatly on the experience of both MD postdoctoral and PhD Predoctoral trainees. The end result is a stronger, more vibrant training environment which, with the recruitment of additional MD and PhD faculty, is more conducive/supportive of translational research. This blended training environment is very much needed if we are to maintain a future pool of interdisciplinary translational research team members to pursue the research and translational goals of NICHD to improve public health as it relates to pregnancy and reproduction.

Public Health Relevance

Research scientists focused on the fields of pregnancy and reproduction are clearly of value to American public health. Nonetheless the increasing complexity of such research means there may not be enough qualified scientists in the future for our health needs. The ERP Program is one of only a handful of research centers qualified to train these future scientists, and we propose here a training program plan to achieve that goal.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD041921-18
Application #
9928435
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Taymans, Susan
Project Start
2004-05-01
Project End
2023-04-30
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
18
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Zywicki, Micaela E; Blohowiak, Sharon E; Magness, Ronald R et al. (2018) Impact of the ovarian cycle and pregnancy on plasma chemistry values in ewes. J Vet Diagn Invest 30:238-244
Jallow, Fatou; Brockman, Jennifer L; Helzer, Kyle T et al. (2018) 17?-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes. J Endocr Soc 2:293-309
Kenealy, Brian P; Keen, Kim L; Garcia, James P et al. (2017) Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys. Proc Natl Acad Sci U S A 114:13804-13809
Degner, Kenna; Magness, Ronald R; Shah, Dinesh M (2017) Establishment of the Human Uteroplacental Circulation: A Historical Perspective. Reprod Sci 24:753-761
Hackbart, Katherine S; Bender, Robb W; Carvalho, Paulo D et al. (2017) Effects of propylene glycol or elevated luteinizing hormone during follicle development on ovulation, fertilization, and early embryo development. Biol Reprod 97:550-563
Ampey, Bryan C; Ampey, Amanda C; Lopez, Gladys E et al. (2017) Cyclic Nucleotides Differentially Regulate Cx43 Gap Junction Function in Uterine Artery Endothelial Cells From Pregnant Ewes. Hypertension 70:401-411
Boeldt, D S; Bird, I M (2017) Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia. J Endocrinol 232:R27-R44
Rodriguez, Adriana M; Jin, Dexter X; Wolfe, Adam D et al. (2017) Brachyury drives formation of a distinct vascular branchpoint critical for fetal-placental arterial union in the mouse gastrula. Dev Biol 425:208-222
Rodriguez, Adriana M; Downs, Karen M (2017) Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula. Dev Biol 432:98-124
Wolfe, Adam D; Rodriguez, Adriana M; Downs, Karen M (2017) STELLA collaborates in distinct mesendodermal cell subpopulations at the fetal-placental interface in the mouse gastrula. Dev Biol 425:44-57

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