This is a revised application for the first competing renewal for the NICHD Institutional Training Grant for Pediatricians (T32 HD043010 Training of the Pediatric Physician-Scientist) at Washington University School of Medicine. Our long-term objective is to utilize this funding to promote the career development of young pediatric physician scientists who will become the future leaders in the biomedical research efforts dedicated to child health.
The specific aims of this proposal are to identify potential trainees at the completion of their residency training or in the midst of fellowship training and to provide them with a three year research experience in the laboratory of a qualified mentor, protected from clinical and teaching responsibilities and with a specific research focus relevant to pediatrics. During the initial funding period ten excellent candidates were supported (including seven women and one under-represented minority). Our long-term objective and specific aims remain unchanged in this renewal application; however, we have significantly expanded the scope of our program with the development of two pathways (basic science and clinical/translational science). We shall achieve our long-term objective by applying the recent advances in genetic and genomic sciences to an understanding of the pathogenesis and treatment of a broad spectrum of diseases within the Pediatric arena. In order to accomplish this we shall combine the established areas of investigative strengths of the Washington University School of Medicine and its Department of Pediatrics. We have now incorporated a new area of emphasis (Pathway B), namely clinical and translational genomic medicine which includes genetic epidemiology, biostatistics, and patient oriented research. Our program will ultimately close the gap between basic biologists and pediatric clinicians. We have in place a structure in which bright, motivated, young pediatricians shall flourish in a protected environment and will emerge as leaders in an evolving area of Pediatrics. Alan L. Schwartz, Ph.D., M.D. will continue to serve as P.I. and Jonathan D. Gitlin, M.D. and Michael DeBaun, M.D., M.P.H. will continue as co-Program Directors. The program (via this award and matched funds from Washington University School of Medicine) takes advantage of 34 established investigators who will serve as mentors to our trainees. The long-term goals of the program will be realized as its trainees contribute to the development of and leadership as pediatric physician-scientists during the next two or more decades. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
2T32HD043010-06A1
Application #
7425633
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Huang, Terry T-K
Project Start
2002-07-01
Project End
2013-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
6
Fiscal Year
2008
Total Cost
$252,695
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Halabi, Carmen M; Mecham, Robert P (2018) Elastin purification and solubilization. Methods Cell Biol 143:207-222
Levy, Philip T; Patel, Meghna D; Choudhry, Swati et al. (2018) Evidence of Echocardiographic Markers of Pulmonary Vascular Disease in Asymptomatic Infants Born Preterm at One Year of Age. J Pediatr 197:48-56.e2
Rosen, David A; Twentyman, Joy; Hunstad, David A (2018) High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung. Infect Immun 86:
Halabi, Carmen M; Broekelmann, Thomas J; Lin, Michelle et al. (2017) Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries. Sci Adv 3:e1602532
Levy, Philip T; El-Khuffash, Afif; Patel, Meghna D et al. (2017) Maturational Patterns of Systolic Ventricular Deformation Mechanics by Two-Dimensional Speckle-Tracking Echocardiography in Preterm Infants over the First Year of Age. J Am Soc Echocardiogr 30:685-698.e1
Orandi, A B; Baszis, K W; Dharnidharka, V R et al. (2017) Assessment, classification and treatment of calcinosis as a complication of juvenile dermatomyositis: a survey of pediatric rheumatologists by the childhood arthritis and rheumatology research alliance (CARRA). Pediatr Rheumatol Online J 15:71
Akhirome, Ehiole; Walton, Nephi A; Nogee, Julie M et al. (2017) The Complex Genetic Basis of Congenital Heart Defects. Circ J 81:629-634
Clark, Amy L; Urano, Fumihiko (2016) Endoplasmic reticulum stress in beta cells and autoimmune diabetes. Curr Opin Immunol 43:60-66
Sindhar, Sampat; Lugo, Michael; Levin, Mark D et al. (2016) Hypercalcemia in Patients with Williams-Beuren Syndrome. J Pediatr 178:254-260.e4
Jay, Patrick Y; Akhirome, Ehiole; Magnan, Rachel A et al. (2016) Transgenerational cardiology: One way to a baby's heart is through the mother. Mol Cell Endocrinol 435:94-102

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