This is a competing renewal for the NICHD Institutional Training Grant for Pediatricians (T32 HD043010, Training of the Pediatric Physician-Scientist) at Washington University School of Medicine. Our long-term objective is to utilize this funding to promote the career development of young pediatric physician scientists who will become the future leaders in the biomedical research efforts dedicated to child health.
The aims of this proposal are to identify potential trainees at the completion of their residency training or in the midst of fellowship training, and to provide them with a two-three year research experience in the laboratory of a qualified mentor, protected from clinical and teaching responsibilities and with a specific research focus relevant to pediatrics. During the recently completed funding period, nine excellent candidates were supported (including six women and one under-represented minority). Five have completed training and three of these have received K awards. Our long-term objective and aims remain unchanged in this renewal application; however, we have significantly expanded the scope of our program with the development of two pathways (basic science and translational medicine). We shall achieve our long-term objective by applying the recent advances in the sciences to an understanding of the pathogenesis and treatment of a broad spectrum of diseases within the Pediatric arena. In order to accomplish this, we shall combine the established areas of investigative strengths of the Washington University School of Medicine and the Department of Pediatrics. We have now incorporated a new area of emphasis (Track II); namely, translational medicine which includes epidemiology, biostatistics, and patient- oriented research. Our program will ultimately close the gap between basic biologists and pediatric clinicians. We have in place a structure in which bright, motivated, young physicians shall flourish in a protected environment and will emerge as leaders in an evolving area of Pediatrics. Alan L. Schwartz, Ph.D., M.D. will continue to serve as P.I. and Mary Dinauer, M.D., Ph.D. will serve as Training Director. The program takes advantage of 34 established investigators across Washington University School of Medicine who will serves as mentors to our trainees. The long-term goals of the program will be realized as its trainees contribute to the development of and leadership as pediatric physician-scientists during the next two or more decades.

Public Health Relevance

Despite the tremendous advances in basic science and biomedical research over the past two decades, we now have an increasing shortage of training opportunities for pediatricians who intend to pursue research careers directed at diagnosis, treatment and prevention of disorders of infants and children. Translation of discoveries into substantial improvements in child health requires that the imagination and creativity of young trainees be nurtured in the most exciting and productive research environments. This proposal is intended to accomplish this.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DRG-D (59))
Program Officer
Winer, Karen
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Medicine
Saint Louis
United States
Zip Code
Halabi, Carmen M; Mecham, Robert P (2018) Elastin purification and solubilization. Methods Cell Biol 143:207-222
Levy, Philip T; Patel, Meghna D; Choudhry, Swati et al. (2018) Evidence of Echocardiographic Markers of Pulmonary Vascular Disease in Asymptomatic Infants Born Preterm at One Year of Age. J Pediatr 197:48-56.e2
Rosen, David A; Twentyman, Joy; Hunstad, David A (2018) High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung. Infect Immun 86:
Halabi, Carmen M; Broekelmann, Thomas J; Lin, Michelle et al. (2017) Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries. Sci Adv 3:e1602532
Levy, Philip T; El-Khuffash, Afif; Patel, Meghna D et al. (2017) Maturational Patterns of Systolic Ventricular Deformation Mechanics by Two-Dimensional Speckle-Tracking Echocardiography in Preterm Infants over the First Year of Age. J Am Soc Echocardiogr 30:685-698.e1
Orandi, A B; Baszis, K W; Dharnidharka, V R et al. (2017) Assessment, classification and treatment of calcinosis as a complication of juvenile dermatomyositis: a survey of pediatric rheumatologists by the childhood arthritis and rheumatology research alliance (CARRA). Pediatr Rheumatol Online J 15:71
Akhirome, Ehiole; Walton, Nephi A; Nogee, Julie M et al. (2017) The Complex Genetic Basis of Congenital Heart Defects. Circ J 81:629-634
Clark, Amy L; Urano, Fumihiko (2016) Endoplasmic reticulum stress in beta cells and autoimmune diabetes. Curr Opin Immunol 43:60-66
Sindhar, Sampat; Lugo, Michael; Levin, Mark D et al. (2016) Hypercalcemia in Patients with Williams-Beuren Syndrome. J Pediatr 178:254-260.e4
Jay, Patrick Y; Akhirome, Ehiole; Magnan, Rachel A et al. (2016) Transgenerational cardiology: One way to a baby's heart is through the mother. Mol Cell Endocrinol 435:94-102

Showing the most recent 10 out of 55 publications