The goal of the Children's Hospital of Philadelphia (CHOP) NICHD-sponsored Institutional Ruth L. Kirschstein National Research Service Award (NRSA) is to increase the number and effectiveness of subspecialty pediatricians with rigorous training in basic, translational, and clinical research. We accomplish this goal by training outstanding pediatric fellows to become successful physician-scientists, addressing questions of fundamental importance to health and disease in children. Candidates for our program are enrolled in our subspecialty fellowship programs and are identified through national searches for the best and the brightest, with aggressive diversity recruitment. Each candidate identifies a prospective mentor from a large group of mentors at CHOP and at the University of Pennsylvania (Penn). These CHOP-T32-NRSA mentors were selected based on the following criteria: rigorous science in areas germaine to pediatrics, a record of successful mentoring and collaboration, a strong record of extramural funding, and programmatic balance. Trainee progress is reviewed twice a year by our Internal Advisory Committee. Trainees are supported for two years to conduct research as outlined in their formal proposals. Trainees in clinical investigation pursue a master's degree in one of several available programs, and trainees in basic and translational research have access to a wide variety of outstanding mentors and educational opportunities, all supported by a wide array of clinical and laboratory research cores. Our T32-NRSA and the companion K12- CHRCDA grant have been highly successful in training physician-scientists who are capable of conducting independent research and who have consistently assumed academic positions. This renewal of our CHOP-T32-NRSA will continue the tradition established during the first 12 years of this grant, taking advantage of the tremendous strengths of CHOP as an academic pediatric institution with an outstanding pool of subspecialty fellows, a large number of experienced mentors, and cutting edge research programs. CHOP and Penn provide a comprehensive, well- supported and resource-intense environment, as well as a proven track record of training academic investigators in basic, translational, and clinical research. The training of physician-scientists in pediatric subspecialties is critical for advancing the understanding and treatment of childhood diseases, and for providing future leaders in academic medicine.

Public Health Relevance

There is a significant shortage of well-trained academic pediatric subspecialists. Our goal is to increase the number and effectiveness of subspecialty pediatricians with rigorous background and skills in basic and translational research. In turn, these individuals speed the transfer of knowledge gained through studies in basic and translational science to clinical applications that will benefit the health of children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
2T32HD043021-11A1
Application #
8853018
Study Section
Special Emphasis Panel (ZHD1-DSR-Y (90))
Program Officer
Winer, Karen
Project Start
2002-07-01
Project End
2020-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
11
Fiscal Year
2015
Total Cost
$286,266
Indirect Cost
$20,194
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hill, David A; Lim, Hee-Woong; Kim, Yong Hoon et al. (2018) Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue. Proc Natl Acad Sci U S A 115:E5096-E5105
Henrickson, Sarah E; Manne, Sasikanth; Dolfi, Douglas V et al. (2018) Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection. Cell Rep 22:411-426
Hill, David A; Grundmeier, Robert W; Ramos, Mark et al. (2018) Eosinophilic Esophagitis Is a Late Manifestation of the Allergic March. J Allergy Clin Immunol Pract 6:1528-1533
Ruffner, Melanie A; Henrickson, Sarah E; Chilutti, Marianne et al. (2018) Improving allergy office scheduling increases patient follow up and reduces asthma readmission after pediatric asthma hospitalization. Ann Allergy Asthma Immunol 121:561-567
Hill, David A; Spergel, Jonathan M (2018) The atopic march: Critical evidence and clinical relevance. Ann Allergy Asthma Immunol 120:131-137
Ruffner, Melanie A; Brown-Whitehorn, Terri F; Verma, Ritu et al. (2018) Clinical tolerance in eosinophilic esophagitis. J Allergy Clin Immunol Pract 6:661-663
Hill, David A; Leahy, Allison Barz; Sciasci, Joseph et al. (2018) Medication contaminants as a potential cause of anaphylaxis to vincristine. Pediatr Blood Cancer 65:
Henrickson, Sarah E; Walter, Jolan E; Quinn, Colin et al. (2018) Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency. J Clin Immunol 38:642-645
Raje, Nikita; Snyder, Brenda L; Hill, David A et al. (2018) Severe immunodeficiency associated with acute lymphoblastic leukemia and its treatment. Ann Allergy Asthma Immunol 120:537-538.e1
Le Coz, Carole; Nolan, Brian E; Trofa, Melissa et al. (2018) Cytotoxic T-Lymphocyte-Associated Protein 4 Haploinsufficiency-Associated Inflammation Can Occur Independently of T-Cell Hyperproliferation. Front Immunol 9:1715

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