The overarching goal of the mixed predoctoral and postdoctoral T32HD071866 training program is to develop burgeoning scientists into future leaders in translational rehabilitation research ? scientists who are equipped to test and disseminate novel rehabilitative strategies that will alleviate impairment and compromised life quality in the face of chronic disease management. To meet this goal, we will build on achievements during the first funding cycle, as the program grew in number of trainees and established a reputation that attracts high caliber applicants nationwide. The now proven program leverages an exceptionally rich institutional environment that offers myriad resources, and a collaborative team that has grown to 50 productive mentors in three categories (Core, Content, Mentors-in-Training); all of whom are deeply committed to training and career development. Trainees benefit from two years of interdisciplinary training that carefully meld three core levels of scientific inquiry: (i) molecular pathobiology; (ii) rehabilitation science/physiology; and (iii) rehabilitation medicine (i.e. clinical trials). Consequent to recent successes in faculty recruitment ? seeding more interdisciplinary teams ? translational rehabilitation research training in the renewal period will expand to four areas of concentrated strength: (i) Musculoskeletal Disorders; (ii) Neurologic Diseases; (iii) Cardiometabolic Diseases; or (iv) Cancer. Predoctoral trainees are selected from a highly competitive and diverse national pool admitted to a UAB graduate program (e.g., Graduate Biomedical Sciences, Rehabilitation Science). Nationally recruited postdoctoral trainees leverage institutionally funded training/career development programs tailored to meet diverse postdoctoral training goals. Each trainee's primary mentor and Translational Mentoring Team are drawn from expert program faculty in the Schools of Medicine (cell/integrative biology; physical medicine & rehabilitation; neurology; pathology; medicine; surgery; oncology; pediatrics; biomedical engineering), Health Professions (rehabilitation & nutrition sciences), Public Health (biostatistics; epidemiology), and Arts & Sciences (psychology). Together the trainee, mentor, and Translational Mentoring Team craft an individual development plan, approved and monitored semi-annually by the Executive Committee. The plan includes coursework, laboratory and clinical research, professional development programs, workshops, presentations locally and at national meetings, and training in the responsible conduct of research. Learning to conduct and publish high-impact research is a primary focus. The program will continue mentoring 4 predoctoral and 4 postdoctoral trainees each year, and will leverage expanded resources to maximize recruitment and training of underrepresented minorities and individuals with disabilities. As a top 25 NIH-funded academic medical center with over 80 state-of-the-art scientific core facilities and 24 University-wide, interdisciplinary research centers, the University of Alabama at Birmingham is remarkably well-positioned to cultivate truly translational scientists equipped to drive the field of rehabilitation medicine with cutting edge research.

Public Health Relevance

The main goal of this training program is to develop highly competitive junior scientists into future leaders in rehabilitation research. This goal will be met by taking advantage of a rich academic environment that offers numerous resources and a complementary and collaborative team of basic and clinical research mentors committed to training and career development. The program will teach both predoctoral and postdoctoral trainees how to conduct, and the importance of, integrative research that spans from understanding disease at the cellular level to improving clinical rehabilitation practices.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD071866-09
Application #
9922132
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Nitkin, Ralph M
Project Start
2012-09-04
Project End
2022-04-30
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
9
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Hightower, Rylie M; Alexander, Matthew S (2018) Genetic modifiers of Duchenne and facioscapulohumeral muscular dystrophies. Muscle Nerve 57:6-15
Kelly, Neil A; Hammond, Kelley G; Stec, Michael J et al. (2018) Quantification and characterization of grouped type I myofibers in human aging. Muscle Nerve 57:E52-E59
Baird, Jessica F; Motl, Robert W (2018) Response Heterogeneity With Exercise Training and Physical Activity Interventions Among Persons With Multiple Sclerosis. Neurorehabil Neural Repair :1545968318818904
Serafini, Peter R; Feyder, Michael J; Hightower, Rylie M et al. (2018) A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies. JCI Insight 3:
Baird, Jessica F; Sandroff, Brian M; Motl, Robert W (2018) Therapies for mobility disability in persons with multiple sclerosis. Expert Rev Neurother 18:493-502
Harms, Ashley S; Thome, Aaron D; Yan, Zhaoqi et al. (2018) Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease. Exp Neurol 300:179-187
Butts, Brittany; Higgins, Melinda; Dunbar, Sandra et al. (2018) The Third Time's a Charm: Psychometric Testing and Update of the Atlanta Heart Failure Knowledge Test. J Cardiovasc Nurs 33:13-21
Roberts, Brandon M; Lavin, Kaleen M; Many, Gina M et al. (2018) Human neuromuscular aging: Sex differences revealed at the myocellular level. Exp Gerontol 106:116-124
Bamman, Marcas M; Roberts, Brandon M; Adams, Gregory R (2018) Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy. Cold Spring Harb Perspect Med 8:
Demark-Wahnefried, Wendy; Schmitz, Kathryn H; Alfano, Catherine M et al. (2018) Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin 68:64-89

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