This is a competitive renewal application of The Stanford Genome Training Program, which is one of the first NHGRI sponsored program established in 1995. This program has been highly successful and has supported and trained 119 graduate students and 44 postdoctoral fellows since it began; many of these have gone on to become leaders in their field. This application proposes to modestly increase its number of Trainees to 28 predoctoral fellows and 6 postdoctoral fellows from its existing level, consistent with its substantial increase in expansion of the program. There are presently 60 Participating Faculty in 15 different departments at Stanford. Research opportunities abound in broad areas of genomics and computational biology including genome characterization, medical genomics, technology development, comparative genomics, diversity and variation, development genomics, proteomics and metabolomics, gene regulation and systems biology, all with an omics emphasis. Organisms that are studied include yeast, flies, worms, fish, mice, and humans and other primates (chimpanzees, gorillas, and orangutans). The emphasis of the SGTP will be to continue to provide a broad interdisciplinary education to a wide range to trainees, to serve to coordinate genomic research and training activities across the entire campus, and to help disseminate genomic science by preparing Trainees for the next steps in their careers. The program contains many unique elements that prepare Trainees for genomics research and highly successful careers. In addition, the SGTP proposes to continue an active Diversity Action Plan (DAP). The DAP will continue to recruit, retain and train individuals of diverse backgrounds for careers in the genomic sciences.)

Public Health Relevance

The field of genomics is a rapidly expanding area that will impact all areas of science including medicine. The SGTP plans to train graduate students and postdoctoral fellows to not only have highly successful careers in this area, but form the next generation of leaders in this field in both academia, industry and related professions. )

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HG000044-19
Application #
8913704
Study Section
Ethical, Legal, Social Implications Review Committee (GNOM)
Program Officer
Junkins, Heather
Project Start
1995-09-01
Project End
2017-08-31
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
19
Fiscal Year
2015
Total Cost
$1,418,725
Indirect Cost
$76,562
Name
Stanford University
Department
Genetics
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304
Ofir, Gal; Melamed, Sarah; Sberro, Hila et al. (2018) DISARM is a widespread bacterial defence system with broad anti-phage activities. Nat Microbiol 3:90-98
Deng, Tanggang; Yan, Guobei; Song, Xin et al. (2018) Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses. Proc Natl Acad Sci U S A 115:4678-4683
de la Fuente, Constanza; Ávila-Arcos, María C; Galimany, Jacqueline et al. (2018) Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia. Proc Natl Acad Sci U S A 115:E4006-E4012
Karczewski, Konrad J; Snyder, Michael P (2018) Integrative omics for health and disease. Nat Rev Genet 19:299-310
Rappoport, Nadav; Toung, Jonathan; Hadley, Dexter et al. (2018) A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth. Sci Rep 8:226
Thompson, Abbey C; Capellini, Terence D; Guenther, Catherine A et al. (2018) A novel enhancer near the Pitx1 gene influences development and evolution of pelvic appendages in vertebrates. Elife 7:
Mezger, Anja; Klemm, Sandy; Mann, Ishminder et al. (2018) High-throughput chromatin accessibility profiling at single-cell resolution. Nat Commun 9:3647
Rong-Mullins, Xiaoqing; Ayers, Michael C; Summers, Mahmoud et al. (2018) Transcriptional Profiling of Saccharomyces cerevisiae Reveals the Impact of Variation of a Single Transcription Factor on Differential Gene Expression in 4NQO, Fermentable, and Nonfermentable Carbon Sources. G3 (Bethesda) 8:607-619
Bahrami-Nejad, Zahra; Zhao, Michael L; Tholen, Stefan et al. (2018) A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation. Cell Metab 27:854-868.e8
Zhou, Coral Y; Johnson, Stephanie L; Lee, Laura J et al. (2018) The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding. Mol Cell 69:677-688.e9

Showing the most recent 10 out of 327 publications