The Nutrition, Obesity and Atherosclerosis Training Program at the University of Washington is a successful Training Program, now in its 35th year of funding. The overall goal of the program continues to be to provide a highly qualified group of postdoctoral MD clinicians and PhD scientists with the research skills they need to become fully independent biomedical investigators in the areas of nutrition, obesity and atherosclerosis. The training program utilizes 26 investigators at the University of Washington who are performing both basic and clinical research in these areas as preceptors. Use is also made of a number of basic and clinical scientists with whom the core faculty collaborates to broaden research opportunities and resources available to trainees in the program. Trainees entering the program previously have obtained either an MD or PhD degree and MD candidates usually have completed residency training. Some have had some prior research experience. PhD candidates have demonstrated ability in a basic science discipline and have demonstrated capability for research related to the focus of this program. Selection of the 4 candidates supported by this training grant is made by an Executive Committee from a large pool of qualified applicants who continue to apply for research training in metabolism, endocrinology and nutrition at the University of Washington. This program provides trainees with research experience in both basic and clinical science necessary in preparation for independent research careers. Appointments to the Training Program are for at least 2 years, with an optional 3rd year available. The program also includes opportunities for trainees to interact through program-specific meetings, and to present their research to peers, preceptors, and invited scientists from other academic institutions. A series of didactic lectures and seminars related to the topics of lipids, obesity, nutrition and atherosclerosis, as well as in scientific methods and biomedical ethics, complement the research training. Rigorous evaluation of trainees and preceptors is performed bi-annually and is overseen by the Executive Committee and an External Advisory Committee. The Nutrition, Obesity and Atherosclerosis Training Program has been highly successful in training productive scientists, including minority scientists, in these areas during the current funding period, and will provide an even stronger training environment due to several changes in overview, coherence, and training opportunities during the next funding period.

Public Health Relevance

Nutrition and obesity are the major contributors to the cardiovascular disease epidemic in the United States and worldwide. A major reason for the increase in cardiovascular disease is the rapidly increasing prevalence of obesity in both adults and children, many of whom will develop cardiovascular disease, and so the burden on our society is tremendous. The Nutrition, Obesity and Atherosclerosis Training Program trains new generations of postdoctoral MD clinicians and PhD scientists to tackle these problems.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Wang, Ke; Zelnick, Leila R; Hoofnagle, Andrew N et al. (2018) Alteration of HDL Protein Composition with Hemodialysis Initiation. Clin J Am Soc Nephrol 13:1225-1233
Rubinow, Katya B; Houston, Barbara; Wang, Shari et al. (2018) Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice. Asian J Androl 20:276-283
Rubinow, Katya B (2018) An intracrine view of sex steroids, immunity, and metabolic regulation. Mol Metab 15:92-103
Galitzine, Cyril; Egertson, Jarrett D; Abbatiello, Susan et al. (2018) Nonlinear Regression Improves Accuracy of Characterization of Multiplexed Mass Spectrometric Assays. Mol Cell Proteomics 17:913-924
Rubinow, Katya B; Vaisar, Tomas; Chao, Jing H et al. (2018) Sex steroids mediate discrete effects on HDL cholesterol efflux capacity and particle concentration in healthy men. J Clin Lipidol 12:1072-1082
Henderson, Clark M; Shulman, Nicholas J; MacLean, Brendan et al. (2018) Skyline Performs as Well as Vendor Software in the Quantitative Analysis of Serum 25-Hydroxy Vitamin D and Vitamin D Binding Globulin. Clin Chem 64:408-410
Deem, Jennifer D; Muta, Kenjiro; Ogimoto, Kayoko et al. (2018) Leptin regulation of core body temperature involves mechanisms independent of the thyroid axis. Am J Physiol Endocrinol Metab 315:E552-E564
Dorfman, Mauricio D; Krull, Jordan E; Scarlett, Jarrad M et al. (2017) Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes 66:920-934
Spencer, Sandra E; Corso, Thomas N; Bollinger, James G et al. (2017) Automated Trapping Column Exchanger for High-Throughput Nanoflow Liquid Chromatography. Anal Chem 89:2383-2389
Rubinow, Katya B; Henderson, Clark M; Robinson-Cohen, Cassianne et al. (2017) Kidney function is associated with an altered protein composition of high-density lipoprotein. Kidney Int 92:1526-1535

Showing the most recent 10 out of 82 publications