? ? The Case Hematology Training Program is a pre- and postdoctoral training program designed to develop expertise in hematology related research. Having been in existence for 29 years, the program has a long history of developing successful basic and clinical scientists, and the past 5 years of this award have been nightly productive. The focus of the training program for individual trainees varies depending upon their background, interests and goals. The majority of trainees will be predoctoral students and Ph.D. postdoctoral fellows, who will pursue an intensive laboratory-based program supplemented with didactic sessions designed to provide a broad education in hematology. Postdoctoral M.D. fellows will comprise approximately 25% of the trainees, and have the opportunity to pursue either a laboratory-based or clinical research track, with the goal being to prepare the trainee for a successful career in basic, translational, or clinical research in hematology. The Hematology training program has been significantly strengthened since the last submission primarily due to the inclusion of new young investigators recruited to Case, as well as enhanced collaborations with scientists at the Lerner Research Institute of the Cleveland Clinic Foundation. Moreover, a new administration at the Case School of Medicine, led by Dean Ralph Horwitz, has devoted substantial effort toward strengthening graduate education, as well as the recruitment of minorities. A new Office of Graduate Education at Case, directed by Alison Hall, Ph.D., opened in 2004. This office offers many new resources for trainees, including comprehensive training on """"""""research survival skills"""""""" such as grant writing and public speaking. Taken together, the broad, multidisciplinary and collaborative approach to training, the outstanding physical and human resources of the Case School of Medicine, Lerner Research Institute and other participating institutions, and the strong institutional support of graduate training at Case, combine to make the Case Hematology training program an excellent resource for trainees at all career stages who are interested in developing careers focused on hematology research. (End of Abstract) ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007147-33
Application #
7431655
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Chang, Henry
Project Start
1990-07-01
Project End
2011-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
33
Fiscal Year
2008
Total Cost
$425,957
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Lavik, Andrew R; Zhong, Fei; Chang, Ming-Jin et al. (2015) A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2. Oncotarget 6:27388-402
Roth, Justin C; Alberti, Michael O; Ismail, Mourad et al. (2015) MGMT enrichment and second gene co-expression in hematopoietic progenitor cells using separate or dual-gene lentiviral vectors. Virus Res 196:170-80
Chang, Ming-Jin; Zhong, Fei; Lavik, Andrew R et al. (2014) Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival. Proc Natl Acad Sci U S A 111:1186-91
Greenberg, Edward F; Lavik, Andrew R; Distelhorst, Clark W (2014) Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment. Biochim Biophys Acta 1843:2205-10
Allen, Kristi L; Fonseca, Fabio V; Betapudi, Venkaiah et al. (2012) A novel pathway for human endothelial cell activation by antiphospholipid/anti-ýý2 glycoprotein I antibodies. Blood 119:884-93
Grimberg, Brian T; Scheetz, Emily A; Erickson, John J et al. (2012) Increased reticulocyte count from cord blood samples using hypotonic lysis. Exp Parasitol 132:304-7
Zhong, Fei; Harr, Michael W; Bultynck, Geert et al. (2011) Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction. Blood 117:2924-34
Molitoris, Jason K; McColl, Karen S; Swerdlow, Sarah et al. (2011) Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes. J Biol Chem 286:30181-9
Molitoris, Jason K; McColl, Karen S; Distelhorst, Clark W (2011) Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis. Mol Endocrinol 25:409-20
Allen, Kristi L; Hamik, Anne; Jain, Mukesh K et al. (2011) Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors. Blood 117:6383-91

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