The primary objective of the Pediatric Hematology Research Training Program, which will complete its 25th year of funding in 2001, has been to prepare pediatricians for careers in academic medicine and biomedical research. In the current application, we week to expand the trainee population to include Ph.D.-trained scientists and pre-doctoral candidates as well.
Specific aims i nclude (1) the provision of research training opportunities in a wide variety of areas including hemoglobinopathies, megakarocytes and platelets, immunohematology, stem cell development, molecular diagnostic techniques, molecular oncology, molecular basis of hemostasis and thrombosis and gene therapy; (2) the opportunity for structured course work in cell and molecular biology, immunology, biochemistry, gene transfer biostatistics and research design, and epidemiology; (3) careful monitoring of the progress of individual trainees and the overall success of the training program; and (4) an emphasis on skills and accomplishments critical for successful academic careers such as preparation of manuscripts, presentations at seminars and national meetings, and submission of grant applications. The training faculty consists of a closely knit group of 15 scientists who have strong records as mentors and productive investigators, who have competed successfully for NIH and other federal funding, and who have interacted for many years in training, and research activities. Extended research training is offered in a fellowship program designed to develop independent, funded investigators. Training opportunities have been enhanced by the opening of a new, state-of-the-art research facility, the recruitment of new, outstanding faculty members, the renewal of the NIH Comprehensive Sickle Cell Center, and the awarding of new program project grants in the area of gene transfer for hemophilia. The program has emphasized the research training of minority students at all levels in order to direct these individuals into biomedical careers. Despite a national trend away from pediatric subspecialty research training and toward clinical practice, the Pediatric Hematology Research Training Program continues to attract outstanding candidates and to prepare them for careers as biomedical investigators in academic institutions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007150-30
Application #
7020062
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Chang, Henry
Project Start
1976-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
30
Fiscal Year
2006
Total Cost
$121,048
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gollomp, Kandace; Kim, Minna; Johnston, Ian et al. (2018) Neutrophil accumulation and NET release contribute to thrombosis in HIT. JCI Insight 3:
George, Lindsey A (2017) Hemophilia gene therapy comes of age. Blood Adv 1:2591-2599
George, Lindsey A (2017) Hemophilia gene therapy comes of age. Hematology Am Soc Hematol Educ Program 2017:587-594
Greineder, Colin F; Johnston, Ian H; Villa, Carlos H et al. (2017) ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model. Blood Adv 1:1452-1465
George, Lindsey A; Sullivan, Spencer K; Giermasz, Adam et al. (2017) Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant. N Engl J Med 377:2215-2227
Russell, Stephen; Bennett, Jean; Wellman, Jennifer A et al. (2017) Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Lancet 390:849-860
Oved, Joseph H; Lee, Christina S Y; Bussel, James B (2017) Treatment of Children with Persistent and Chronic Idiopathic Thrombocytopenic Purpura: 4 Infusions of Rituximab and Three 4-Day Cycles of Dexamethasone. J Pediatr 191:225-231
Arruda, Valder R; Doshi, Bhavya S; Samelson-Jones, Benjamin J (2017) Novel approaches to hemophilia therapy: successes and challenges. Blood 130:2251-2256
Bdeir, Khalil; Gollomp, Kandace; Stasiak, Marta et al. (2017) Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury. Am J Respir Cell Mol Biol 56:261-270
Gollomp, Kandace; Lambert, Michele P; Poncz, Mortimer (2017) Current status of blood 'pharming': megakaryoctye transfusions as a source of platelets. Curr Opin Hematol 24:565-571

Showing the most recent 10 out of 47 publications