The proposed renewal is for a continuation of the present Multidisciplinary Training Program in Lung Disease (HL-07185), which provides training in basic and clinical sciences important to the respiratory system. The program depends on the interdisciplinary staff of the Cardiovascular Research Institute, together with specialized basic and clinical research skills of other members of the UCSF campus. The grant is to accommodate a total of sixteen postdoctoral trainees (approximately eight new trainees per year), including both MD's and PhDs. The main focus of the program is an actual experience in the laboratory under the close supervision of a Staff Member, employing one or more of several approaches applicable at the molecular, cellular, tissue, organ, whole animal or clinical levels. In addition, considerable emphasis is placed on special educational opportunities that have been created to prepare individuals for a career in academic medicine. The educational program provides special courses, small group conferences, seminars (including ethical scientific conduct) and personal instruction specifically designed for trainees as well as basic science courses. Courses for Clinical Scholars include courses in biostatistics, epidemiology, clinical research design, and medical economics. New facilities and faculty have been added to incorporate the disciplines of modern biology and the disciplines relevant to rigorous clinical research. Considerable emphasis has been placed on (a) the multidisciplinary focus of the program, (b) developing and implementing academic careers in areas of scientific need, especially in those currently underrepresented. These areas in our program include bacterial pathogenesis, immunology, genetics, mouse biology, and the development of clinical research support programs; (c) mentorship of trainees in the laboratory, and in the development of their academic careers; (d) the recruitment and retention of underserved minorities and women in the program; (e) clinical research training and close coordination with basic science. The interdisciplinary nature of the program and the close collaboration among a widely diverse staff are major strengths.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Rothgeb, Ann E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
Zip Code
Famous, Katie R; Delucchi, Kevin; Ware, Lorraine B et al. (2017) Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy. Am J Respir Crit Care Med 195:331-338
Vinnikov, Denis; Blanc, Paul D; Alilin, Alaena et al. (2017) Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea. Health Qual Life Outcomes 15:48
Wang, Richard J; Miller, Robert F; Huang, Laurence (2017) Approach to Fungal Infections in Human Immunodeficiency Virus-Infected Individuals: Pneumocystis and Beyond. Clin Chest Med 38:465-477
Shete, P B; Nalugwa, T; Farr, K et al. (2017) Feasibility of a streamlined tuberculosis diagnosis and treatment initiation strategy. Int J Tuberc Lung Dis 21:746-752
Faust, Hilary E; Golden, Jeffrey A; Rajalingam, Raja et al. (2017) Short lung transplant donor telomere length is associated with decreased CLAD-free survival. Thorax 72:1052-1054
Xi, Ying; Kim, Thomas; Brumwell, Alexis N et al. (2017) Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol 19:904-914
Jayakumar, A; Savic, R M; Everett, C K et al. (2016) Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure. J Clin Microbiol 54:3028-3033
Hendrickson, Carolyn M; Howard, Benjamin M; Kornblith, Lucy Z et al. (2016) The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg 80:989-97
Kanegai, Cindy M; Xi, Ying; Donne, Matthew L et al. (2016) Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol 55:613-615
Walter, Nicholas D; Miller, Mikaela A; Vasquez, Joshua et al. (2016) Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: a Case-Control Study with Systematic Cross-Classifier Evaluation. J Clin Microbiol 54:274-82

Showing the most recent 10 out of 102 publications