This T32 Program, which is in its 39th year, is dedicated to the training of cardiovascular scientists with MD and/or PhD degrees. Over the past 20 years, the program has been based in the Cardiovascular Research Center (CVRC) of the Massachusetts General Hospital (MGH), and has focused heavily on training in molecular and cellular biology. Over the last 5 years the program has expanded its scope to include additional areas of investigation including genomics, metabolomics, molecular imaging, as well as systems and computational biology. During the next cycle of this award we will continue to broaden the scope of the training program, which we now title ?Integrated, Multidisciplinary Training In Cardiovascular Research.? This expanded focus is a reflection of our evolving faculty and exciting scientific developments in an era where the boundaries between rigorous basic, translational, and clinical investigation blur. Graduates of the Training Program have been highly successful in multiple ways: publishing their findings in high-profile journals, obtaining extramural funding, and securing outstanding faculty positions. The large majority of past trainees (96%) continue to focus on research, with academic appointments as faculty or research and leadership positions in industry. Nearly half (48%) have been awarded career development grants (K-award or equivalent), 5 in the current cycle alone. We anticipate that these numbers will rise further as the current fellows complete their training and submit career development awards. New faculty have been recruited to the award to enable trainees to benefit from dramatic recent advances in cardiovascular science. The 33 faculty members on the award are recognized leaders in their evolving fields, as well as proven, outstanding mentors. Training is firmly centered on an intensive research experience under the supervision of skilled primary and secondary mentors, with unique opportunities for innovation at the interface between fields. Didactic experiences are tailored to the needs of the trainee and are designed to broaden their scientific exposure. Support is provided for 3 trainees at any given time to obtain a Masters in Public (MPH) or similar degrees and all trainees receive mandatory training in the responsible conduct of research. The faculty and trainees are closely linked by a tradition of collaboration and a shared training mission. The CVRC/T32 seminar series, cardiology grand rounds, CVRC retreat, and ?Science Social? meetings serve to bring trainees and faculty together on a regular basis. Trainee progress is closely monitored by the mentors and co-mentors, as well as the Program Director and Associate Directors. The Program Director provides regular updates to an External Advisory Committee, and a concerted effort is made to recruit and retain underrepresented minority candidates. As demonstrated by the strong track record of this Training Program, graduates are rigorously and systematically prepared to lead independent research programs at the cutting edge of cardiovascular science.
This Program, which is in its 39th year, trains cardiovascular scientists with MD and/or PhD degrees to become independent researchers who can thrive in multi-disciplinary collaborative environments at the cutting edge of cardiovascular science. Career development centers on an intensive research experience, supplemented by coursework and seminars tailored to the trainee's experience and needs. The faculty and trainees are closely linked by a tradition of outstanding mentorship, which is taught, evaluated and valued.
|Benson, Mark D; Yang, Qiong; Ngo, Debby et al. (2018) Genetic Architecture of the Cardiovascular Risk Proteome. Circulation 137:1158-1172|
|Hu, Ray; Morley, Michael P; Brandimarto, Jeffrey et al. (2018) Genetic Reduction in Left Ventricular Protein Kinase C-? and Adverse Ventricular Remodeling in Human Subjects. Circ Genom Precis Med 11:e001901|
|Jacob, Jaison; Ngo, Debby; Finkel, Nancy et al. (2018) Application of Large-Scale Aptamer-Based Proteomic Profiling to Planned Myocardial Infarctions. Circulation 137:1270-1277|
|Khera, Amit V; Chaffin, Mark; Aragam, Krishna G et al. (2018) Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet 50:1219-1224|
|Jordi, Josua; Guggiana-Nilo, Drago; Bolton, Andrew D et al. (2018) High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy. Sci Adv 4:eaav1966|
|Paffett-Lugassy, Noelle; Novikov, Natasha; Jeffrey, Spencer et al. (2017) Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field. Development 144:4616-4624|
|Tucker, Nathan R; McLellan, Micheal A; Hu, Dongjian et al. (2017) Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy. Circ Cardiovasc Genet 10:|
|Tucker, Nathan R; Dolmatova, Elena V; Lin, Honghuang et al. (2017) Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential. Circ Cardiovasc Genet 10:|
|Strauss, David G; Vicente, Jose; Johannesen, Lars et al. (2017) Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. Circulation 135:1300-1310|
|Hucker, William J; Hanley, Alan; Ellinor, Patrick T (2017) Improving Atrial Fibrillation Therapy: Is There a Gene for That? J Am Coll Cardiol 69:2088-2095|
Showing the most recent 10 out of 188 publications