EXCEED THE SPACE PROVIDED. This is a renewal application for years 25-30 of a broad, multidisciplinary research training program based in the Division of Physiology of the Dept of Medicine at UCSD. The interests of the 14 Division faculty have broadened from pulmonary to skeletal muscle structure and function, all in the context of O2transport and its regulation, and encompass approaches at the cellular and molecular levels while still retaining an integrative systems physiologyemphasis. In skeletal muscle, for example, the role of VEGF in angiogenesis is being addressed by its Cre/loxP targeted gene deletion; also, we are investigating the causal links between VEGF gene activation and physiological responses to exercise such as hypoxia, blood flow, mechanical factors, acidosis or other stimuli. Trainees study the mouse, rat, normal man and humans with cardiopulmonary disease in an effort to better understand the role of the muscles per se in the exercise intolerance of chronic disease. Similar gene regulation approaches are applied to mechanismsof the hypoxic ventilatory CNS response , and responses to physical stress in the lungs. These examples and the rest of the research program are supported by several national grantsa longstanding PPG (HL17731, Wagner) that hasjust been renewed for years 25-30 (2000-2005); two ROl's: HL40155 (Hogan) and HL60968 (West); and several NASA grants (West, Prisk). Many of our young faculty and students have been successful in garnering small support grants in their own name as well (from the AHA, ALA, TRDRP, NIH, UCSD, PBF). The student complement is full, with several new students signed up to join us over the coming year. The objective of our program continues to be to prepare students (both postdoctoral [MD or PhD] and predoctoral) for academic careers in research and teaching. The program has several formal educational opportunities (seminars, laboratory discussions, ethics in science course, methods lectures and journal club) for all students. As judged by subsequent employment and by publications,the program continues to be successful and is a major element of the Physiology Division's contributions to UCSD. PERFORMANCE SITE ========================================Section End===========================================
| Wilkinson, Katherine A; Huey, Kimberly; Dinger, Bruce et al. (2010) Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system. J Appl Physiol (1985) 109:424-30 |
| Watson, Rebecca R; Fu, Zhenxing; West, John B (2008) Minimal distensibility of pulmonary capillaries in avian lungs compared with mammalian lungs. Respir Physiol Neurobiol 160:208-14 |
| Wray, D Walter; Nishiyama, Steven K; Harris, Ryan A et al. (2008) Angiotensin II in the elderly: impact of angiotensin II type 1 receptor sensitivity on peripheral hemodynamics. Hypertension 51:1611-6 |
| Beck, Stayce E; Jung, Barbara H; Del Rosario, Eunice et al. (2007) BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. Cell Signal 19:1465-72 |
| Wray, D Walter; Nishiyama, Steven K; Donato, Anthony J et al. (2007) Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans. Am J Physiol Heart Circ Physiol 293:H2550-6 |
| Watson, Rebecca R; Fu, Zhenxing; West, John B (2007) Morphometry of the extremely thin pulmonary blood-gas barrier in the chicken lung. Am J Physiol Lung Cell Mol Physiol 292:L769-77 |
| Beck, Stayce E; Carethers, John M (2007) BMP suppresses PTEN expression via RAS/ERK signaling. Cancer Biol Ther 6:1313-7 |
| Jung, Barbara H; Beck, Stayce E; Cabral, Jennifer et al. (2007) Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin. Gastroenterology 132:633-44 |
| Chow, Jimmy Y C; Quach, Khai T; Cabrera, Betty L et al. (2007) RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. Carcinogenesis 28:2321-7 |
| Beck, Stayce E; Jung, Barbara H; Fiorino, Antonio et al. (2006) Bone morphogenetic protein signaling and growth suppression in colon cancer. Am J Physiol Gastrointest Liver Physiol 291:G135-45 |
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