We have assembled a group of 41 mentors, from 7 departments and 3 divisions in the School of Medicine, all of whom are committed to training young investigators interested in the study of the heart and vasculature. Faculty research focus areas include: biophysics and molecular biology of receptors and ion channels, cell signaling, growth control of vascular smooth muscle, microvascular regulation, molecular basis of leukocyte-endothelial cell interactions, and genetic engineering of the vascular system. Our laboratories are supplemented by a superb array of shared-instrumentation and core facilities, both in the Cardiovascular Research Center and in the School of Medicine. The training program supports 10 pre-doctoral Ph.D. candidates who initially enter into interdisciplinary programs which provide the widest possible exposure to the opportunities in our biomedical departments. In the second year, after determining their desired career trajectory, the trainees enroll in a department, and then in our training grant. Degrees are granted by departments, which establish criteria for professional excellence in a discipline, whereas the training grant requirements assure competencies for quality cardiovascular research. Eight post-doctoral fellows are also supported, and their training is under the primary direction of their mentor(s), aided by consultation with the Training Grant Executive Committee. The central aim of the post-doctoral program is to complete the training of independent scientist-scholars. Accordingly, the fellows are treated as colleagues, and commonly interact with more than one faculty member during the training period. Didactic education of both pre- and postdoctoral fellows is supplemented by a cardiovascular research journal club, laboratory discussion groups, and an outstanding seminar program hosted by the Cardiovascular Research Center in conjunction with the participating departments and divisions. Trainees are an integral part of the educational program with their presentaion at Reasearch in Progress Seminars, teacing in mini-courses, and participation in a high school science training program. Preparation for translational research is fostered by: the inclusion of faculty from three clinical departments with those from the basic sciences, and by intermixing clinical and basics science fellows. Also, we have now formalized a plan for PhD training for a group of our MD Fellows. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007284-32
Application #
7447893
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Commarato, Michael
Project Start
1977-07-01
Project End
2012-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
32
Fiscal Year
2008
Total Cost
$689,457
Indirect Cost
Name
University of Virginia
Department
Physiology
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Wilson, Rebecca J; Drake, Joshua C; Cui, Di et al. (2018) Mitochondrial protein S-nitrosation protects against ischemia reperfusion-induced denervation at neuromuscular junction in skeletal muscle. Free Radic Biol Med 117:180-190
Heuslein, Joshua L; McDonnell, Stephanie P; Song, Ji et al. (2018) MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis. Front Bioeng Biotechnol 6:1
Martins, André L; Walavalkar, Ninad M; Anderson, Warren D et al. (2018) Universal correction of enzymatic sequence bias reveals molecular signatures of protein/DNA interactions. Nucleic Acids Res 46:e9
Woo, Laura A; Tkachenko, Svyatoslav; Ding, Mei et al. (2018) High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets. J Mol Cell Cardiol :
DeLalio, Leon J; Keller, Alexander S; Chen, Jiwang et al. (2018) Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure. Arterioscler Thromb Vasc Biol 38:2065-2078
Adamson, Samantha E; Polanowska-Grabowska, Renata; Marqueen, Kathryn et al. (2018) Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report. Arterioscler Thromb Vasc Biol 38:1020-1029
Hong, Kwangseok; Cope, Eric L; DeLalio, Leon J et al. (2018) TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction. Arterioscler Thromb Vasc Biol 38:542-554
Good, Miranda E; Chiu, Yu-Hsin; Poon, Ivan K H et al. (2018) Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. Circ Res 122:606-615
Rickel, J M Robert; Dixon, Adam J; Klibanov, Alexander L et al. (2018) A flow focusing microfluidic device with an integrated Coulter particle counter for production, counting and size characterization of monodisperse microbubbles. Lab Chip 18:2653-2664
Anderson, Warren D; DeCicco, Danielle; Schwaber, James S et al. (2017) A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation. PLoS Comput Biol 13:e1005627

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