This program brings together 16 Faculty who will provide training to postdoctoral fellows, mild predoctoral students in the broadly defined area of Structural and Cell Biology in cardiovascular Systems. The research includes: 1. Structure and function of chaperones that assemble nucleosomes and snRNPs; 2. Apposis in the mitochondrial pathway-, 3. Mechanisms of protein translocation and membrane protein biogenesis; 4. Chaperonemediated assembly of ApoB on VLDL; 5. Catalytic mechanisms of the debalogenase superfiumily; 6. Structure of aplipoproteins and *proteins (HDL, LDL) and their relevance to atherosclerosis; 7. Cell adhesion by pathogenic bacteria nuxiiated by pili; 8. Interactions of MHC Class I molecules with viral proteins; 9. Mechanisms of autoproteolysis; 10. ApoC- I conformation, folding and structure; 11. Fatty acid transport and its relation to diabetes and obesity; 12. Analyses of lipids in atherosclerotic plaques; 13. The mechanism of MarR in antibiotic resistance; 14. Structure of cardiac actin filaments, including mutants associated with hypertrophic cardiomyopathy; 15. Actin bkxling by normal and mutant dystrophins (muscular-dystrophy); 16. Troponin I peptide binding to actin during cardiac stunning and ischernia; 17. Structure, folding and fiction of actin-binding headpieces; 18. Structure of the N-terminal domain of Apoll; 19. Mechanisms of protein interactions at membrane surfaces (annexins, blood coagulation factors and lung surfactant proteins); 20. Structure and function of membrane receptor complexes (LDL receptor-LDL; insulin-receptor-insuhn); 21. The roles of immunoglobulin light chains and transthyretin in amyloid formation; and 22. The fiction of complex lipids in cell membranes.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007291-22
Application #
6654899
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Schucker, Beth
Project Start
1977-07-01
Project End
2007-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
22
Fiscal Year
2003
Total Cost
$337,567
Indirect Cost
Name
Boston University
Department
Physiology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Raychaudhury, Suchismita; Farelli, Jeremiah D; Montminy, Timothy P et al. (2009) Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure 17:590-601
Poole, Steven T; McVeigh, Annette L; Anantha, Ravi P et al. (2007) Donor strand complementation governs intersubunit interaction of fimbriae of the alternate chaperone pathway. Mol Microbiol 63:1372-84
Chung, Connie M; Chiu, Jenny D; Connors, Lawreen H et al. (2005) Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma. Biophys J 88:4232-42
Chung, C M; Connors, L H; Benson, M D et al. (2001) Biophysical analysis of normal transthyretin: implications for fibril formation in senile systemic amyloidosis. Amyloid 8:75-83
Peng, S; Guo, W; Morrisett, J D et al. (2000) Quantification of cholesteryl esters in human and rabbit atherosclerotic plaques by magic-angle spinning (13)C-NMR. Arterioscler Thromb Vasc Biol 20:2682-8
Di, L; Small, D M (1995) Physical behavior of the hydrophobic core of membranes: properties of 1-stearoyl-2-linoleoyl-sn-glycerol. Biochemistry 34:16672-7