Abstract

The purpose of this application is to continue the training program devoted to the study of the molecular and cellular basis of cardiovascular disease at the University of Washington School of Medicine. Our proposal attempts to build upon a strong tradition in cell biology training at the pre- and postdoctoral levels. Our focusing continues to be on molecular biology. The extensive collaborative research of our faculty produces a synergistic effect in training, as well as an important bridge between basic and clinical science with major loci of interest in growth control, developmental biology, adherence signaling, as well as more direct studies of vascular pathology in atherosclerosis and hypertension. This program is the major source of support for basic sciences training in vascular biology at the University of Washington and in the Pacific Northwest.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007312-29
Application #
7023887
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Commarato, Michael
Project Start
1978-07-01
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
29
Fiscal Year
2006
Total Cost
$703,844
Indirect Cost

  Institution

Name
University of Washington
Department
Pathology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Powers, Joseph D; Williams, C David; Regnier, Michael et al. (2018) A Spatially Explicit Model Shows How Titin Stiffness Modulates Muscle Mechanics and Energetics. Integr Comp Biol 58:186-193
Raj, Bushra; Wagner, Daniel E; McKenna, Aaron et al. (2018) Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain. Nat Biotechnol 36:442-450
Hofsteen, Peter; Robitaille, Aaron Mark; Strash, Nicholas et al. (2018) ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. iScience 2:88-100
Lee, Su-In; Celik, Safiye; Logsdon, Benjamin A et al. (2018) A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia. Nat Commun 9:42
Kim, Daniel Seung; Li, Yatong K; Kim, Jerry H et al. (2018) Autosomal dominant mannose-binding lectin deficiency is associated with worse neurodevelopmental outcomes after cardiac surgery in infants. J Thorac Cardiovasc Surg 155:1139-1147.e2
Brewer, Chris M; Majesky, Mark W (2018) Branch Point Smooth Muscle Cells Highlighted by Novel Lineage Tracking Approach. Circ Res 122:194-196
Köksal, Ali Sinan; Beck, Kirsten; Cronin, Dylan R et al. (2018) Synthesizing Signaling Pathways from Temporal Phosphoproteomic Data. Cell Rep 24:3607-3618
McKenna, Aaron; Shendure, Jay (2018) FlashFry: a fast and flexible tool for large-scale CRISPR target design. BMC Biol 16:74
Leonard, Andrea; Bertero, Alessandro; Powers, Joseph D et al. (2018) Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues. J Mol Cell Cardiol 118:147-158
Ngambenjawong, Chayanon; Gustafson, Heather H; Pun, Suzie H (2017) Progress in tumor-associated macrophage (TAM)-targeted therapeutics. Adv Drug Deliv Rev 114:206-221

Showing the most recent 10 out of 185 publications