The Washington University School of Medicine Training Program in Principles of Pulmonary Research provides predoctoral and postdoctoral research training in the disciplines of respiratory cell and molecular biology, genetics, immunology, microbiology, pathology, physiology, pharmacology, and radiology. The Program emphasizes scientific approaches critical to understanding mechanisms of lung disease with components of fundamental, translational, and clinical research. A principal goal of the postdoctoral portion of the Training Program is to enable physicians who are completing their clinical training in pulmonary and critical care medicine to then learn how to perform state-of-the-art scientific research. In addition, predoctoral trainees in the M.D./Ph.D. and Ph.D. programs in the Division of Biology and Biomedical Sciences are a vital component of the Program.
The aim of the Program is to promote the scientific growth and maturity of trainees so they may enter academic pulmonary medicine with the skills needed to study problems relevant to understanding respiratory diseases. The core and support training faculty consists of 43 full-time members of the Departments of Biostatistics, Cell Biology/Physiology, Genetics, Internal Medicine, Molecular Biology/Pharmacology, Molecular Microbiology, Pathology/Immunology, Pediatrics, Radiology, and/or Surgery. Current research projects span the gamut of respiratory science. The nature of the faculty and the scientific projects ensures a well-organized, multidisciplinary interface of pulmonary researchers with basic scientists. The program is designed to provide trainees with an intensive laboratory or clinical research experience supplemented by graduate coursework, seminars, research conferences, and scientific journal clubs. In the laboratory, trainees will utilize cutting-edge approaches relevant to their particular investigative area. Basic science courses, seminars and journal clubs will be used to build skills in evaluating scientific literature, identifying important questions, designing experimental approaches, and organizing, analyzing, and presenting scientific data. Each trainee is under the supervision of a mentor and other supervisory experts as needed for the specific project. In addition, trainee progress is monitored by the Program Director and Scientific Advisory Committees. These mechanisms serve to ensure adequate trainee experiences in research techniques, lecture presentation, manuscript preparation, and grant application.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007317-30
Application #
7245056
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F3))
Program Officer
Rothgeb, Ann E
Project Start
1978-07-01
Project End
2008-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
30
Fiscal Year
2007
Total Cost
$647,521
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Kulkarni, Hrishikesh S; Liszewski, M Kathryn; Brody, Steven L et al. (2018) The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target? J Allergy Clin Immunol 141:1582-1586.e1
Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Oltean, Alina; Schaffer, Andrew J; Bayly, Philip V et al. (2018) Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells. Am J Respir Cell Mol Biol 59:511-522
Monin, Leticia; Mehta, Shail; Elsegeiny, Waleed et al. (2018) Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice. Infect Immun 86:
Gregory, Ann C; Sullivan, Matthew B; Segal, Leopoldo N et al. (2018) Smoking is associated with quantifiable differences in the human lung DNA virome and metabolome. Respir Res 19:174
Berry, Kayla N; Kober, Daniel L; Su, Alvin et al. (2018) Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps. Bioessays 40:e1800086
Lyons, Patrick G; Edelson, Dana P; Churpek, Matthew M (2018) Rapid response systems. Resuscitation 128:191-197
Koo, Hyun Young; El-Baz, Lamis Mf; House, StaceyL et al. (2018) Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation. J Pathol 246:54-66
Kulkarni, Hrishikesh S; Witt, Chad A (2018) Voriconazole in lung transplant recipients - how worried should we be? Am J Transplant 18:5-6
Dunlap, Micah D; Howard, Nicole; Das, Shibali et al. (2018) A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis. Mucosal Immunol 11:1727-1742

Showing the most recent 10 out of 135 publications