The Washington University Training Program in Principles of Pulmonary Research provides predoctoral and postdoctoral research training in the disciplines of respiratory cell and molecular biology, genetics, immunology, microbiology, pharmacology, physiology, structural and chemical biology and biochemistry, and developmental biology. The Program emphasizes scientific approaches critical to understanding mechanisms of lung disease with components of fundamental, translational, and clinical research. The postdoctoral portion of the training program enables physicians training in pulmonary and critical care medicine to learn how to perform state-of-the-art scientific research in concert with Ph.D. trainees from a basic science background. In addition, predoctoral trainees in the M.D./Ph.D. and Ph.D. programs in the Division of Biology and Biomedical Sciences are a vital component of the Program.
The aim of the Program is to promote the scientific growth of trainees so they may enter academic pulmonary medicine with the skills needed to study problems relevant to understanding respiratory diseases. The primary and support training faculty consists of 54 full-time members of the Departments of Biostatistics, Biochemistry, Bioengineering, Chemistry, Cell Biology/Physiology, Genetics, Internal Medicine, Molecular Biology/Pharmacology, Microbiology, Pathology/Immunology, Pediatrics, Physics, Radiology, and Surgery. Current research projects span the gamut of respiratory science. The nature of the faculty and the scientific projects ensures a well- organized, multidisciplinary interface of pulmonary researchers with basic scientists. The program is designed to provide trainees with an intensive laboratory or clinical research experience supplemented by graduate coursework and research conferences. In the laboratory, trainees utilize cutting-edge approaches relevant to their particular investigative area. Basic science courses and conferences are used to build skills in evaluating scientific literature, identifying important questions, designing experimental approaches, and organizing, analyzing, and presenting scientific data. Each trainee is under the supervision of a mentor and other supervisory experts as needed for the specific project, and the Program closely monitors trainee and mentor performance. These mechanisms serve to ensure high level trainee experiences in research techniques, lecture presentation, manuscript preparation, grant application, and mentoring.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007317-35
Application #
8293160
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Tigno, Xenia
Project Start
1978-07-01
Project End
2013-07-31
Budget Start
2012-07-01
Budget End
2013-07-31
Support Year
35
Fiscal Year
2012
Total Cost
$486,236
Indirect Cost
$45,399
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Koo, Hyun Young; El-Baz, Lamis Mf; House, StaceyL et al. (2018) Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation. J Pathol 246:54-66
Kulkarni, Hrishikesh S; Witt, Chad A (2018) Voriconazole in lung transplant recipients - how worried should we be? Am J Transplant 18:5-6
Dunlap, Micah D; Howard, Nicole; Das, Shibali et al. (2018) A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis. Mucosal Immunol 11:1727-1742
Kulkarni, Hrishikesh S; Elvington, Michelle L; Perng, Yi-Chieh et al. (2018) Intracellular C3 Protects Human Airway Epithelial Cells from Stress-Associated Cell Death. Am J Respir Cell Mol Biol :
Kulkarni, Hrishikesh S; Liszewski, M Kathryn; Brody, Steven L et al. (2018) The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target? J Allergy Clin Immunol 141:1582-1586.e1
Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Oltean, Alina; Schaffer, Andrew J; Bayly, Philip V et al. (2018) Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells. Am J Respir Cell Mol Biol 59:511-522
Monin, Leticia; Mehta, Shail; Elsegeiny, Waleed et al. (2018) Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice. Infect Immun 86:
Gregory, Ann C; Sullivan, Matthew B; Segal, Leopoldo N et al. (2018) Smoking is associated with quantifiable differences in the human lung DNA virome and metabolome. Respir Res 19:174
Berry, Kayla N; Kober, Daniel L; Su, Alvin et al. (2018) Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps. Bioessays 40:e1800086

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