This application requests continued funding, at a level of eight training positions, for a postdoctoral training program in arteriosclerosis that began in 1978 and was last renewed on July 1, 2008. The goal of this program is to train basic and clinical investigators with broadly based knowledge in the major fields related to arteriosclerosis research. Atherosclerotic cardiovascular disease has a major impact on the health of the American population, making this training program very relevant. This training program functions within a broad framework of research dealing with various aspects of atherosclerotic cardiovascular disease: a strength of the program is the many collaborative interactions that exist between faculty and collaborative research programs for trainees has always been stressed. A group of senior scientists will act as mentors both to postdoctoral trainees working in their laboratories as well as to other trainees in the laboratories of more junior faculty members. The program also includes training in clinical/translational aspects of cardiovascular research. Many of the senior faculty have worked together at Columbia for more than 20 years. They interact through research efforts, joint weekly research conferences, and educational programs such as the Institute of Human Nutrition. Dr. Ira Goldberg, PI and Director of the training program, has been actively engaged as a mentor of young basic and clinical scientists for many years. The former director, Dr. Ginsberg, three associate directors, and leaders of the four training themes form an executive committee that oversees research, admissions, career development and administration. Regardless of the research focus, all trainees will enroll in didactic programs to strengthen their knowledge in biostatistics and clinical trials and to obtain some background in basic laboratory investigation. Mentoring is also a focus of the program. New faculty were added to bring new strengths to the program in vascular biology and translational research. This latter focus includes integration with a newly awarded NIH CTSA. The program will continue to recruit a mix of Ph.D. and M.D. trainees and trainees will work with a mix of M.D. and Ph.D. faculty. A program to enhance recruitment of scientists from underrepresented ethnic groups is in place and has been successful.

Public Health Relevance

This is a long-standing program to train scientists and physician/scientists in arteriosclerosis research. M.D.s and Ph.D.s trainees participate in an integrated clinical and laboratory research training program with a focus on lipoprotein metabolism, atherosclerosis in animal models, angiogenesis, and risk factor modification.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007343-38
Application #
8882500
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
1978-07-01
Project End
2016-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
38
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Proto, Jonathan D; Doran, Amanda C; Gusarova, Galina et al. (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49:666-677.e6
Chang, Chuchun L; Garcia-Arcos, Itsaso; Nyrén, Rakel et al. (2018) Lipoprotein Lipase Deficiency Impairs Bone Marrow Myelopoiesis and Reduces Circulating Monocyte Levels. Arterioscler Thromb Vasc Biol 38:509-519
Proto, Jonathan D; Doran, Amanda C; Subramanian, Manikandan et al. (2018) Hypercholesterolemia induces T cell expansion in humanized immune mice. J Clin Invest 128:2370-2375
Burgermaster, Marissa; Murray, Meghan; Saiman, Lisa et al. (2018) Associations Between Enteral Nutrition and Acute Respiratory Infection Among Patients in New York Metropolitan Region Pediatric Long-Term Care Facilities. Nutr Clin Pract 33:865-871
Ravussin, Yann; Edwin, Ethan; Gallop, Molly et al. (2018) Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding. Cell Metab 28:289-299.e5
Westerterp, Marit; Fotakis, Panagiotis; Ouimet, Mireille et al. (2018) Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis. Circulation 138:898-912
Westerterp, Marit; Gautier, Emmanuel L; Ganda, Anjali et al. (2017) Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity. Cell Metab 25:1294-1304.e6
Burgermaster, Marissa; Koroly, Jenna; Contento, Isobel et al. (2017) A Mixed-Methods Comparison of Classroom Context During Food, Health & Choices, a Childhood Obesity Prevention Intervention. J Sch Health 87:811-822
Yurdagul Jr, Arif; Doran, Amanda C; Cai, Bishuang et al. (2017) Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis. Front Cardiovasc Med 4:86
Katchman, Alexander; Yang, Lin; Zakharov, Sergey I et al. (2017) Proteolytic cleavage and PKA phosphorylation of ?1C subunit are not required for adrenergic regulation of CaV1.2 in the heart. Proc Natl Acad Sci U S A 114:9194-9199

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