EXCEED THE SPACE PROVIDED. This proposed program is a comprehensive, multidisciplinary trainingprogram for cardiovascular scientists. The primary goal of this program will be to provide opportunities for M.D. and Ph.D. trainees to acquire the knowledge and skills necessary to become independentinvestigators in cardiovascular research. Seventy Seven trainees have received support from this trainingprogram since its inception in 1978. Two-thirds now hold faculty positions, nearly half have active research funding .81% continueto actively publish original work. Support is requested for five postdoctoral and two predoctoral positions. Two years of training will be required of all postdoctoral trainees. Trainees will have two years of research experience supported by this proposal. The Faculty of the program are from the Departments of Medicine, Pharmacology and Bioengineering at UCSD and bring the resources of the School of Medicine, School of Engineering, Howard Hughes Medical Institute for Molecular Biology, and the Department of Veterans Affairs Medical center to the training program. Research trainingareas include: Cardiac mechanics, molecular biology, extracellular matrix biology, parasympathetic and adrenergic mechanisms for signal transductionand regulation of gene expression in the normal and failing circulation, cyclicAMP metabolism, central mechanisms of hypertension, cardiac contractility and calcium homeostasis, and mechanisms of myocyte death in ischemia. The program is composed of both didactic and laboratory experiences and emphasizes the breadth of training. Thus most trainees will work in areas that cross both laboratory and disciplinary boundaries. At all stages of the program from selection of trainees through the didactic portions of the program and planned laboratory investigations, thoughtful career planningwill be stressed and the training program tailored to meet an individualtrainee's particular long-term goals in academic medicine and research. PERFORMANCE SITE ========================================Section End===========================================
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