EXCEED THE SPACE PROVIDED. This proposal defines a multi-disciplinary postdoctoral research training program for five graduates of medicine, veterinary medicine, or the basic biomedical sciences. As has been the case for the past 20 years of this NIH-sponsored program, postdoctoral training will encompass research in areas relevant to cardiovascular biology and is provided by well-funded, interactiveresearch programs within the Departments of Biochemistry, Pathology, Medicine, Pharmacology, Physiology, Radiology, and Surgery at the University of Texas Health Science Center at San Antonio (UTHSCSA). Principal components of the training program include: (1) active participation with graded responsibility in the research laboratory of an experienced investigator; (2) a continuing research-in-progress seminar series; (3) an integrated lecture series on topics in cardiovascular biology presented by the training faculty; (4) a didactic course in the responsible conduct of research; and, if necessary, (5) a course in biostatistics for biological research. Trainee access to on-going departmental conferences, seminars, clinical rounds, pre- and postdoctoral courses further enhances the training experience. Research areas are encompassed within four investigative themes: (1) Vascular Pathobiology/Inflammation; (2) Cardiovascular Pathophysiology; (3) Cell Injury/Adaptation; and, (4) Diabetes and Genetic/Clinical Epidemiology. These overlapping research themes incorporate a range of highly relevant basic biomedical science investigations which are essential for our understanding of the genetic and biochemical mechanisms that contribute to cardiovascular pathobiology. The integration of educational activities within these research themes will insure that postdoctoral trainees obtain a comprehensive, but fundamental overview of research studies which address the multi-dimensional complexities of cardiovascular disease. PERFORMANCE SITE ========================================Section End===========================================
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