This Training Program, Mechanisms of Hypertension and Cardiovascular Diseases, Suzanne Oparil, MD, PD/PI, offers postdoctoral training in fundamental aspects of the pathophysiology of hypertension and cardiovascular (CV) diseases and in innovative approaches to the treatment of these conditions. The Program has recently been enriched to include new training opportunities in free radical biology, vascular inflammation, atherogenesis, matrix biology, obesity/metabolism, statistical genetics and genomics, cardiac remodeling/ failure, and arrhythmogenesis, as well as clinical and translational research in chronic kidney disease, diabetes/metabolism and resistant hypertension. The UAB CCTS offers advanced training in quantitative sciences, including bioinformatics, systems biology and computational techniques, that will augment our existing Program and equip trainees to function in these important new research areas. The UAB Office for Postdoctoral Education (OPE) offers our trainees valuable guidance and instruction in survival skills, including counseling re-career opportunities in academia and the biotechnology/pharmaceutical industry. Our multidisciplinary faculty has expertise in molecular and cell biology, physiology, biostatistics, and clinical and translational research. Training opportunities are available in four Thematic Groups: Vascular injury/inflammation/ atherogenesis;oxidative stress/free radical injury;cardiac remodeling/failure, and clinical/ translational research. Each trainee is given in-depth experience in one area of research and will be exposed to other areas through seminars, conferences, and course work. Trainees will have a concentrated 2- 3 year experience in laboratory or clinical/translational research under the direction of mentors from the training faculty. Trainees will spend at least 80% of time in investigation, in taking relevant courses, and in attending scientific meetings. The goal of this Program is to prepare trainees for careers in both fundamental and clinical/translational research in CV disease. The educational experiences available to our trainees are sufficient to equip graduates of the Program with the appropriate technical skills and theoretical background to make them competitive for faculty positions in prestigious academic institutions through the country or in the biotechnology/pharmaceutical industry. Relevance: There is a shortage of basic, translational and clinical scientists who are trained to use cutting edge approaches to problems related to hypertension and cardiovascular disease, a leading cause of death and disability in the US. Ours is the only Program in Alabama that provides highly integrated """"""""bench to bedside"""""""" training in cardiovascular science for MD- and PhD-prepared trainees.

Public Health Relevance

This Training Program, Mechanisms of Hypertension and Cardiovascular Diseases, Suzanne Oparil, MD, PD/PI, offers postdoctoral training in fundamental aspects of the pathophysiology of hypertension and cardiovascular diseases and in innovative approaches to the treatment of these conditions. Training opportunities are available in four Thematic Groups: Vascular injury/inflammation/ atherogenesis; oxidative stress/free radical injury;cardiac remodeling/failure, and clinical/ translational research. The educational experiences available to our trainees are sufficient to equip graduates of the Program with the appropriate technical skills and theoretical background to make them competitive for faculty positions in prestigious academic institutions through the country or in the biotechnology/pharmaceutical industry.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007457-32
Application #
8294718
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1980-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
32
Fiscal Year
2012
Total Cost
$365,771
Indirect Cost
$26,597
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Oduk, Yasin; Zhu, Wuqiang; Kannappan, Ramaswamy et al. (2018) VEGF nanoparticles repair the heart after myocardial infarction. Am J Physiol Heart Circ Physiol 314:H278-H284
Loop, Matthew Shane; van Dyke, Melissa K; Chen, Ligong et al. (2018) Low Utilization of Beta-Blockers Among Medicare Beneficiaries Hospitalized for Heart Failure With Reduced Ejection Fraction. J Card Fail :
Siddiqui, Mohammed; Phillips, Robert A; Bursztyn, Michael et al. (2018) Case of Refractory Hypertension Controlled After Aortic and Mitral Valve Replacement and Coronary Artery Bypass Grafting. Hypertension 72:3-9
Gao, Ling; Gregorich, Zachery R; Zhu, Wuqiang et al. (2018) Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine. Circulation 137:1712-1730
Loop, Matthew Shane; McClure, Leslie A; Levitan, Emily B et al. (2018) Fine particulate matter and incident coronary heart disease in the REGARDS cohort. Am Heart J 197:94-102
Speed, Joshua S; Hyndman, Kelly A; Roth, Kaehler et al. (2018) High dietary sodium causes dyssynchrony of the renal molecular clock in rats. Am J Physiol Renal Physiol 314:F89-F98
Bromfield, Samantha G; Booth 3rd, John N; Loop, Matthew S et al. (2018) Evaluating different criteria for defining a complete ambulatory blood pressure monitoring recording: data from the Jackson Heart Study. Blood Press Monit 23:103-111
Payne, Gregory A; Li, Jindong; Xu, Xin et al. (2017) The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection. Sci Rep 7:7563
Becker, Bryan K; Speed, Joshua S; Powell, Mackenzie et al. (2017) Activation of neuronal endothelin B receptors mediates pressor response through alpha-1 adrenergic receptors. Physiol Rep 5:
Gohar, Eman Y; Kasztan, Malgorzata; Becker, Bryan K et al. (2017) Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis. Am J Physiol Renal Physiol 313:F361-F369

Showing the most recent 10 out of 206 publications