MOLECULAR AND CELLULAR MECHANISMS OF HEART DISEASE This revised training grant renewal application describes a Cardiology research training program at the University of Texas-Houston Medical School that will provide successful applicants with research training in basic molecular biology and physiologically-oriented research laboratories. These laboratories offer research experience in cardiovascular medicine, broadly including endothelial-blood cell interactions; vascular smooth muscle proliferation in response to mechanical and immunologically-mediated injury; cell growth and differentiation, myocardial cell viability based on membrane function and intracellular metabolism; receptor isolation, characterization, cloning, and expression; intracellular signaling, gene cloning and cell transfection; molecular genetics studies aimed at the elucidation of genes responsible for specific cardiovascular disorders; and gene therapy. Health outcomes and epidemiological research opportunities exist in this program at the University of Texas-Houston School of Public Health. We believe that a coordinated and broad training program that provides trainees with research training opportunities in physiologically and clinically oriented research laboratories and in basic molecular biology and immunology laboratories, as well as in health outcomes research opportunities is available in this program. The principal faculty involved in the training program consists of senior, NIH-funded basic scientists and clinical investigators. The Principal Investigator and Director of the training program, the new faculty added to the training program, and the new organization of this competitive renewal reflect expansion and continued effort of the training program into cardiovascular molecular biology and health outcomes research with the expectation of integrating basic molecular biology and clinically oriented research to provide a comprehensive training program in cardiovascular science.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007591-11
Application #
2800318
Study Section
Special Emphasis Panel (ZHL1-CSR-K (F1))
Project Start
1985-07-01
Project End
2004-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
11
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Osterholt, Moritz; Sen, Shiraj; Dilsizian, Vasken et al. (2012) Targeted metabolic imaging to improve the management of heart disease. JACC Cardiovasc Imaging 5:214-26
Thakker, Geeta D; Frangogiannis, Nikolaos G; Zymek, Pawel T et al. (2008) Increased myocardial susceptibility to repetitive ischemia with high-fat diet-induced obesity. Obesity (Silver Spring) 16:2593-600
Essop, M Faadiel; Camp, Heidi S; Choi, Cheol Soo et al. (2008) Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice. Am J Physiol Heart Circ Physiol 295:H256-65
Sharma, Saumya; Guthrie, Patrick H; Chan, Suzanne S et al. (2007) Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart. Cardiovasc Res 76:71-80
Essop, M Faadiel; Chan, W Y A; Taegtmeyer, Heinrich (2007) Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress. FEBS J 274:5278-84
Sharma, Saumya; Ying, Jun; Razeghi, Peter et al. (2006) Atrophic remodeling of the transplanted rat heart. Cardiology 105:128-36
Sharma, Saumya; Dewald, Oliver; Adrogue, Julia et al. (2006) Induction of antioxidant gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species. Free Radic Biol Med 40:2223-31
Dewald, Oliver; Sharma, Saumya; Adrogue, Julia et al. (2005) Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation 112:407-15
Golfman, Leonard S; Wilson, Christopher R; Sharma, Saumya et al. (2005) Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats. Am J Physiol Endocrinol Metab 289:E328-36
Adrogue, Julia V; Sharma, Saumya; Ngumbela, Kholiswa et al. (2005) Acclimatization to chronic hypobaric hypoxia is associated with a differential transcriptional profile between the right and left ventricle. Mol Cell Biochem 278:71-8

Showing the most recent 10 out of 16 publications