The proposed research training program is intended to equip physicians and scientists at the postdoctoral levels for independent research-oriented careers in the field of hematology. The program is based on the research interests and expertise of a total of 23 funded faculty members in the pediatric and adult Division of Hematology/Oncology and Nephrology, Departments of Pathology, Microbiology, Immunology, Human Genetics, Anatomy and Cell Biology, and the Howard Hughes Institute at the University of Michigan. Areas of active research of the faculty can be divided into three major groups of interest. These include 1) the molecular and cell biology of the immune system, 2) the molecular basis of cell growth and differentiation, and 3) the molecular and cell biology of blood and endothelial cells, and hemostasis and thrombosis. Trainees will spend 2-3 years in the laboratory under the direct supervision of a faculty preceptor and will be helped to develop expertise in 1) posing feasible scientific questions; 2) acquiring the necessary skills to apply techniques to answer these questions; and 3) critically evaluating the data obtained. The trainees will have M.D., Ph.D., or both degrees. M.D. trainees will have three years of house officer training in Internal Medicine or Pediatrics an a year of clinical training in adult or pediatric selection committees. The adult program will have 4-5 fellows in the first year of clinical training, all M.D. trainees are actively encouraged to participate in the clinical postdoctoral research training program in cell and molecular biology to prepare them for presentations. Once the trainees enter the laboratory, they are monitored constantly by their mentors and yearly by the administrative staff. It is expected that each of the trainees will submit a grant for extramural approval during the course of their training and first author a research manuscript. Multiple research conferences attended by trainees and research faculty are held weekly. Trainees are expected to present the results of their ongoing investigations and to participate in the discussions of data obtained by their colleagues. Trainees are encouraged to attend relevant research seminars and to interact with faculty members in basic sciences. Additionally, the trainees are encouraged to take courses in relevant basic sciences which would enhance their research interests. It is the goal of this training program to produce trainees who will be successful in pursuing careers in academic Hematology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007622-18
Application #
6627430
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Chang, Henry
Project Start
1986-07-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
18
Fiscal Year
2003
Total Cost
$390,690
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Rost, Megan S; Shestopalov, Ilya; Liu, Yang et al. (2018) Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood Adv 2:3418-3427
Khoriaty, Rami; Hesketh, Geoffrey G; Bernard, Amélie et al. (2018) Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo. Proc Natl Acad Sci U S A 115:E7748-E7757
Peltier, Daniel; Reddy, Pavan (2018) Non-Coding RNA Mediated Regulation of Allogeneic T Cell Responses After Hematopoietic Transplantation. Front Immunol 9:1110
Jin, Xi; Qin, Tingting; Zhao, Meiling et al. (2018) Oncogenic N-Ras and Tet2 haploinsufficiency collaborate to dysregulate hematopoietic stem and progenitor cells. Blood Adv 2:1259-1271
Hu, Zhilian; Liu, Yang; Huarng, Michael C et al. (2017) Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway. Blood 130:666-676
Miller, Holly K; Braun, Thomas M; Stillwell, Terri et al. (2017) Infectious Risk after Allogeneic Hematopoietic Cell Transplantation Complicated by Acute Graft-versus-Host Disease. Biol Blood Marrow Transplant 23:522-528
Rost, M S; Grzegorski, S J; Shavit, J A (2016) Quantitative methods for studying hemostasis in zebrafish larvae. Methods Cell Biol 134:377-89
Pedersen, Elisabeth A; Menon, Rajasree; Bailey, Kelly M et al. (2016) Activation of Wnt/?-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States. Cancer Res 76:5040-53
Bailey, Kelly M; Airik, Merlin; Krook, Melanie A et al. (2016) Micro-Environmental Stress Induces Src-Dependent Activation of Invadopodia and Cell Migration in Ewing Sarcoma. Neoplasia 18:480-8
Weyand, Angela C; Lombel, Rebecca M; Pipe, Steven W et al. (2016) The Role of Platelets and ?-Aminocaproic Acid in Arthrogryposis, Renal Dysfunction, and Cholestasis (ARC) Syndrome Associated Hemorrhage. Pediatr Blood Cancer 63:561-3

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