This is a multi-disciplinary, postdoctoral research training program sponsored by the Cardiology Unit of the Department of Medicine and the Departments of Molecular Physiology and Biophysics and Pharmacology of the University of Vermont. The current submission is a competitive renewal of a program first initiated in July, 1988. Previously, three positions have been funded. We request an increase to a total of five positions in this renewal application. The goal of the program is to provide rigorous research training to both MDs and PhDs in order to equip them for productive academic careers. MD trainees are recruited primarily in conjunction with the clinical training program in cardiovascular disease at the University of Vermont, while PhDs are recruited through the two basic science departments. All training positions have been filled since the initiation of this program. The participating faculty is divided into four research categories: 1) cardiac muscle, 2) smooth muscle, 3) vascular biology, and 4) clinical cardiology. The research training is centered on a mentored laboratory or clinical research experience. Interactions with participating faculty within each research category and across boundaries are encouraged and facilitated. Trainees are required to take courses in biostatistics and bioinstrumentation if they have adequate prior backgrounds in these areas. Administrative and policy oversight and monitoring of trainees' progress is accomplished by a Steering Committee composed of the PI, Dr. Martin LeWinter, Director of the Cardiology Unit, and Dr. David Warshaw, Chair of Molecular Physiology and Biophysics, and Dr. Mark Nelson, Chair of Pharmacology. The philosophy of the training program faculty is to provide a truly multi-disciplinary experience which includes both a focussed research plan and opportunities for and understanding of collaborative interactions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007647-13
Application #
6343390
Study Section
Special Emphasis Panel (ZHL1-CSR-K (F1))
Program Officer
Commarato, Michael
Project Start
1994-07-01
Project End
2004-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
13
Fiscal Year
2001
Total Cost
$188,002
Indirect Cost
Name
University of Vermont & St Agric College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Moon, Thomas M; Sheehe, Jessica L; Nukareddy, Praveena et al. (2018) An N-terminally truncated form of cyclic GMP-dependent protein kinase I? (PKG I?) is monomeric and autoinhibited and provides a model for activation. J Biol Chem 293:7916-7929
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Callahan, Damien M; Tourville, Timothy W; Slauterbeck, James R et al. (2015) Reduced rate of knee extensor torque development in older adults with knee osteoarthritis is associated with intrinsic muscle contractile deficits. Exp Gerontol 72:16-21
Meyer, Markus; McEntee, Rachel K; Nyotowidjojo, Iwan et al. (2015) Relationship of exercise capacity and left ventricular dimensions in patients with a normal ejection fraction. An exploratory study. PLoS One 10:e0119432
Tykocki, Nathan R; Nelson, Mark T (2015) Location, Location, Location: Juxtaposed calcium-signaling microdomains as a novel model of the vascular smooth muscle myogenic response. J Gen Physiol 146:129-32
Tanner, Bertrand C W; McNabb, Mark; Palmer, Bradley M et al. (2014) Random myosin loss along thick-filaments increases myosin attachment time and the proportion of bound myosin heads to mitigate force decline in skeletal muscle. Arch Biochem Biophys 552-553:117-27

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