This is a competitive renewal of a multi-disciplinary, post-doctoral cardiovascular research program sponsored by the Cardiology Unit of the Dept. of Medicine and the Depts. of Molecular Physiology and Biophysics and Pharmacology of the University of Vermont College of Medicine. The grant was first funded in 1988. With this competitive renewal, we are requesting an increase from four to five positions. The goal of the program is to provide rigorous training for both MDs and PhDs that will equip them for productive research careers in cardiovascular science. MD trainees are recruited primarily in conjunction with the clinical Cardiology Fellowship Program at the University of Vermont, while PhDs are mainly recruited through the two basic science departments. All positions have been filled since the initiation of this grant. The 16 participating faculty are divided into four thematic groups: 1) cardiac muscle, 2) smooth muscle, 3) vascular biology, and 4) clinical cardiology. Training is centered around a focused laboratory or clinical research experience under the supervision of a primary mentor and one or more secondary mentors. Interactions with participating faculty within each thematic group and across boundaries are encouraged and facilitated. Trainees in Clinical Cardiology take required seminar courses in study design and biostatistics, which are open to other trainees if they are deemed useful or necessary. All trainees attend a seminar series on responsible conduct of research. Administrative and policy decisions and overall oversight of trainees' progress is accomplished by a Steering Committee composed of the PI, Drs. David Warshaw and Mark Nelson, Chairs of Molecular Physiology and Biophysics and Pharmacology, respectively. The philosophy of the training program is to provide both focus and flexibility, a collaborative environment, and carefully designed, supportive mentoring relationships.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHL1-CSR-G (F1))
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Varghese, Jamie
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University of Vermont & St Agric College
Internal Medicine/Medicine
Schools of Medicine
United States
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Moon, Thomas M; Sheehe, Jessica L; Nukareddy, Praveena et al. (2018) An N-terminally truncated form of cyclic GMP-dependent protein kinase I? (PKG I?) is monomeric and autoinhibited and provides a model for activation. J Biol Chem 293:7916-7929
Rengo, Jason L; Callahan, Damien M; Savage, Patrick D et al. (2016) Skeletal muscle ultrastructure and function in statin-tolerant individuals. Muscle Nerve 53:242-51
Heppner, Thomas J; Tykocki, Nathan R; Hill-Eubanks, David et al. (2016) Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling. J Gen Physiol 147:323-35
Previs, Michael J; Mun, Ji Young; Michalek, Arthur J et al. (2016) Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function. Proc Natl Acad Sci U S A 113:3239-44
Callahan, Damien M; Tourville, Timothy W; Miller, Mark S et al. (2015) Chronic disuse and skeletal muscle structure in older adults: sex-specific differences and relationships to contractile function. Am J Physiol Cell Physiol 308:C932-43
Moon, Thomas M; Tykocki, Nathan R; Sheehe, Jessica L et al. (2015) Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase I?. Chem Biol 22:1653-61
Callahan, Damien M; Tourville, Timothy W; Slauterbeck, James R et al. (2015) Reduced rate of knee extensor torque development in older adults with knee osteoarthritis is associated with intrinsic muscle contractile deficits. Exp Gerontol 72:16-21
Meyer, Markus; McEntee, Rachel K; Nyotowidjojo, Iwan et al. (2015) Relationship of exercise capacity and left ventricular dimensions in patients with a normal ejection fraction. An exploratory study. PLoS One 10:e0119432
Tykocki, Nathan R; Nelson, Mark T (2015) Location, Location, Location: Juxtaposed calcium-signaling microdomains as a novel model of the vascular smooth muscle myogenic response. J Gen Physiol 146:129-32
Callahan, Damien M; Bedrin, Nicholas G; Subramanian, Meenakumari et al. (2014) Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function. J Appl Physiol (1985) 116:1582-92

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