? ? Advances in our understanding and treatment of childhood respiratory disorders have been limited by a lack of insight into basic mechanisms of disease and the development of novel therapeutic strategies. The purpose of this program is to provide rigorous multidisciplinary training for academically oriented pediatricians interested in childhood lung diseases. This proposal is a renewal of the NIH Training Program in Pediatric Pulmonary Lung Disease at the University of Colorado School of Medicine, and represents the continuation of a well-established program that has existed since 1988. This current proposal has been expanded to represent the evolution of our training program and to reflect our highly interactive, multidisciplinary faculty. Strengths of this program include benefits derived fro the integration of extensive resources of two collaborating hospitals (The Children's Hospital (TCH) and National Jewish Medical and Research Center (NJMRC)) and five research units at the NJMRC and the UCHSC campus (Developmental Lung Biology Laboratory, Pediatric Heart Lung Center Laboratory, the Perinatal Research Facility, and the Cardiovascular Pulmonary Laboratories). These resources are combined into a versatile training environment for both basic and applied research. Faculty in this program include the PIs of 2 PPGs, 2 SCORs, a Therapeutic Development Center Award in Cystic Fibrosis, and NIH Clinical Research Center Grant, and several individual awards that address basic, applied and clinical research questions in the area of pulmonary biology. Collaborations between laboratory and clinical investigators are a major strength of this proposal, enhancing interactions between scientists and clinicians from diverse backgrounds and encouraging """"""""bench to bedside"""""""" approaches to pediatric lung disease. All participants in the training program are full-time academic faculty, and include pediatric pulmonary and critical care physician investigators, along with several basic (PhD) and other scientists from throughout the UCHSC. The most promising individuals with clearly defined academic goals are selected from candidates within our pediatric pulmonary, critical care and neonatology fellowship training programs. After a clinical year of training (funded from other sources), laboratory or clinical research experience is provided under the direct mentorship of a senior investigator. Structured course work in statistics, molecular biology, cell physiology, ethics, and other areas are provided to the trainees. The head of the training grant, fellowship directors, their laboratory mentor and special advisors to the program closely monitors review of fellows' progress. ? (End of Abstract) ? ? ?

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Rothgeb, Ann E
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University of Colorado Denver
Schools of Medicine
United States
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McGraw, Matthew D; Sherlock, Laura G; Bailey, Kolene L et al. (2018) Developmental Origins of Chronic Lung Diseases. Mechanical Stretch, Micro-RNAs, and Hydrogels. Am J Respir Cell Mol Biol 59:267-270
McGraw, Matthew D; Dysart, Marilyn M; Hendry-Hofer, Tara B et al. (2018) Bronchiolitis Obliterans and Pulmonary Fibrosis after Sulfur Mustard Inhalation in Rats. Am J Respir Cell Mol Biol 58:696-705
Messinger, Amanda I; Deterding, Robin R; Szefler, Stanley J (2018) Bringing Technology to Day-to-Day Asthma Management. Am J Respir Crit Care Med 198:291-292
Peters, Erica B (2018) Endothelial Progenitor Cells for the Vascularization of Engineered Tissues. Tissue Eng Part B Rev 24:1-24
Okponyia, Obiefuna C; McGraw, Matthew D; Dysart, Marilyn M et al. (2018) Oxygen Administration Improves Survival but Worsens Cardiopulmonary Functions in Chlorine-exposed Rats. Am J Respir Cell Mol Biol 58:107-116
McGraw, Matthew D; Osborne, Christopher M; Mastej, Emily J et al. (2017) Editor's Highlight: Pulmonary Vascular Thrombosis in Rats Exposed to Inhaled Sulfur Mustard. Toxicol Sci 159:461-469
Bush, Douglas; Deterding, Robin; Weinman, Jason et al. (2017) Hypoxemia in Lipoid Pneumonia: Role of Intrapulmonary Bronchopulmonary Anastomoses. Am J Respir Crit Care Med 195:1531-1532
McGraw, Matthew D; Galambos, Csaba; Stillwell, Paul C (2017) Uremic pleuritis: A case report and review of recurrent exudative pleural effusions in children. Pediatr Pulmonol 52:E52-E54
Hawkins, Stephen; Huston, Stephanie; Campbell, Kristen et al. (2017) High-Flow, Heated, Humidified Air Via Nasal Cannula Treats CPAP-Intolerant Children With Obstructive Sleep Apnea. J Clin Sleep Med 13:981-989
McGraw, Matthew D; Rioux, Jaqueline S; Garlick, Rhonda B et al. (2017) From the Cover: ImpairedProliferation and Differentiation of the Conducting Airway Epithelium Associated With Bronchiolitis Obliterans After Sulfur Mustard Inhalation Injury in Rats. Toxicol Sci 157:399-409

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