Cardiovascular disease remains the primary cause of morbidity and mortality in the developed world. There continues to be a need for outstanding scientist-educators to increase our basic understanding of cardiovascular disease and to translate this information into clinical application. The Training Program in """"""""Molecular Physiology of the Cardiovascular System"""""""" (MFCS) at Baylor College of Medicine is a multidisciplinary program with 32 participating faculty from 7 basic science and 9 clinical departments. The MFCS training program has trained 32 predoctoral and 68 postdoctoral trainees since its inception in 1989. Currently, the mentors are primarily located at Baylor College of Medicine (BCM), Rice University (RU), MD Anderson Cancer Center, Methodist Hospital, and the Texas A&M Health Sciences Center Institute for Biosciences and Biotechnology (IBT). The major goal for our program is to train biomedical scientists (5 predoctoral and 7 postdoctoral trainees) to work at the interface of basic and clinical research in one of four specialized themes, related to cardiovascular research. These themes include: 1) Electrophyslology & excitability, 2) Development and stem cells, 3) Stroke and cerebrovascular disease, and 4) Tissue engineering and novel therapeutic strategies. The strong collaborative research infrastructure at Baylor College of Medicine and partner institutions in the Texas Medical Center, and the diverse background of our mentors (basic scientists and practicing clinicians), provide unique resources for the trainees affiliated with the MFCS training program. The MFCS trainees will participate in an interdisciplinary training program comprised of didactic courses, grant writing workshops, journal clubs, seminar series, ethics training, and regular interactions with training faculty. Moreover, the pre- and postdoctoral fellows will be trained as leaders of teams of scientists and physicians that collaborate in translational research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007676-22
Application #
8146020
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1994-07-01
Project End
2015-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
22
Fiscal Year
2011
Total Cost
$459,490
Indirect Cost
Name
Baylor College of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Nikolaev, Sergey I; Vetiska, Sandra; Bonilla, Ximena et al. (2018) Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain. N Engl J Med 378:250-261
Herman, Alexander M; Rhyner, Alexander M; Devine, W Patrick et al. (2018) A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. Biol Open 7:
Tanner, Mark R; Pennington, Michael W; Chamberlain, Brayden H et al. (2018) Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis. J Pharmacol Exp Ther 365:227-236
Loehr, James Anthony; Wang, Shang; Cully, Tanya R et al. (2018) NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. Elife 7:
Jarrett, Kelsey E; Lee, Ciaran; De Giorgi, Marco et al. (2018) Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. Arterioscler Thromb Vasc Biol 38:1997-2006
Fish, Jason E; Cantu Gutierrez, Manuel; Dang, Lan T et al. (2017) Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development 144:2428-2444
Ren, Pingping; Hughes, Michael; Krishnamoorthy, Swapna et al. (2017) Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. Sci Rep 7:12351
Brinegar, Amy E; Xia, Zheng; Loehr, James Anthony et al. (2017) Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife 6:
Quick, Ann P; Landstrom, Andrew P; Wang, Qiongling et al. (2017) Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. JACC Basic Transl Sci 2:56-67
Jarrett, Kelsey E; Lee, Ciaran M; Yeh, Yi-Hsien et al. (2017) Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep 7:44624

Showing the most recent 10 out of 102 publications