Cardiovascular disease remains a major cause of morbidity and mortality in the U.S. and is increasing worldwide. Application of modern cell biology, genetics, 'omic and other technologies is producing remarkable progress in our understanding of basic processes related to cardiovascular diseases, and the need for broadly trained scientists who can adopt innovative technologies, assemble tools from different disciplines, and bridge basic and clinical science is greater than ever. The overall goal of UCSF Training Program in the Molecular and Cellular Basis of Cardiovascular Disease is to train investigators who will be at the cutting edge of cardiovascular research. Toward this end we: 1) Capitalize on the outstanding research environment of the CVRI and UCSF to provide multidisciplinary training in areas of signaling and cell biology, developmental biology, regeneration and congenital anomalies, ion channels and arrhythmias, vascular biology and atherothrombosis; metabolism, obesity and metabolic diseases; myocyte biology and heart failure; and genetics, biomarkers and disease prevention. (2) Attract graduates of top Ph.D. and M.D.-Ph.D. programs to cardiovascular research and (3) Provide opportunities for M.D.s in clinical fellowships at UCSF to obtain rigorous research training. The Program brings together a diverse and outstanding group of mentors with a common interest in cardiovascular biology within the Cardiovascular Research Institute at UCSF, a multi- departmental and multi-disciplinary research organization. It places trainees in remarkably productive and interactive laboratories. Multi-disciplinary affinity groups, largely co-located in the Smith Cardiovascular Research Building, provide collaborations and co-mentoring to promote acquisition of the knowledge and skills required for success. A major outpatient clinic for patients with cardiovascular diseases in the Smith building helps drive integration of laboratory- and patient-based research.

Public Health Relevance

Cardiovascular diseases remain one of the main causes of premature death and disability in the U.S. and are of increasing importance in the rest of the world. Technologies and approaches to determine the basic mechanisms that cause disease are increasingly powerful but increasingly specialized. Multidisciplinary efforts that bring together investigators with complementary knowledge, tools and skills and integrate laboratory and patient-based research will be required to make progress. This Training Program offers an exceptional faculty in a strong multidisciplinary, collaborative environment at UCSF, a top biomedical research institution, to train future leaders in cardiovascular research.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
Zip Code
Zhang, Qiang; Huang, Hai; Zhang, Luqing et al. (2018) Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell 69:334-346.e4
Bellono, Nicholas W; Leitch, Duncan B; Julius, David (2018) Molecular tuning of electroreception in sharks and skates. Nature 558:122-126
Chang, Aram; Abderemane-Ali, Fayal; Hura, Greg L et al. (2018) A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function. Neuron 97:836-852.e6
Sun, Xin; Hota, Swetansu K; Zhou, Yu-Qing et al. (2018) Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function. Biol Open 7:
Schepis, Antonino; Barker, Adrian; Srinivasan, Yoga et al. (2018) Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. J Cell Biol 217:1097-1112
Raleigh, David R; Choksi, Pervinder K; Krup, Alexis Leigh et al. (2018) Hedgehog signaling drives medulloblastoma growth via CDK6. J Clin Invest 128:120-124
Anderson, Courtney M; Hu, Jianxin; Thomas, Reuben et al. (2017) Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites. Development 144:1235-1241
Polizzi, Nicholas F; Wu, Yibing; Lemmin, Thomas et al. (2017) De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. Nat Chem 9:1157-1164
Graziano, Brian R; Gong, Delquin; Anderson, Karen E et al. (2017) A module for Rac temporal signal integration revealed with optogenetics. J Cell Biol 216:2515-2531
Bellono, Nicholas W; Leitch, Duncan B; Julius, David (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543:391-396

Showing the most recent 10 out of 84 publications