This training program provides two years of basic research training in vascular surgery for academic clinicians and scientists. It addresses the absence of adequate research training for vascular surgeons as it applies to improving interventions and therapeutics of vascular disease. Research training in molecular and cell biology, biomechanics, coagulation thrombosis, angiogenesis and advanced outcomes research is provided with a focus on clinically relevant problems such as atherogenesis, intimal hyperplasia, prosthetic/host interactions and thrombosis. Trainees pursue a program of intense research activity supplemented with course work in research design, statistics, and evaluation of published research. The program is conducted and closely supervised by the program director, co-director and mentors who have well-established records of peer- reviewed research, and who were selected both for the current research activities and their proven commitment to train research fellows. Individual mentors are chosen from the program's faculty on the basis of the background and research interest of the individual trainee, and the trainees carry out their own projects under the close guidance of their mentor. Collaboration between laboratories and sharing of expertise is fostered. Laboratory training can be supplemented by graduate level training at Harvard Medical School, the Department of Health Care Policy and Research and Harvard's Faculty of Arts and Sciences, with course selection complementing laboratory endeavors. Upon completion of the program, trainees are capable of independent research and possess the scientific and research background needed to obtain competitive peer- reviewed grants; they have the abilities and knowledge necessary to provide translational expertise as they join medical school faculties. Selection of the trainees is based on candidates' demonstrated ability and career choice of academic practice and research. Applicants are resident physicians who have completed two, three or five years (i.e. board eligible) of post-graduate surgical training or those who have a PhD with zero to three years of postdoctoral experience. Trainees commit to two years of training; trainees desiring a shorter training period are not considered. Only those applicants with career goals as surgeon-scientists or scientists, with a keen interest in basic research or outcomes research related to vascular surgery, are compatible. Candidates pursuing a fellowship during a program of clinical training must provide evidence that they will be accepted back into that program upon completion of their research training. Trainees are not involved in any clinical activities unless research related.

Public Health Relevance

Vascular Surgeon-scientists guide and provide a practical 'hands on' perspective on the relevant problems and limitations of devices and interventions on blood vessels. This T32 program creates a cadre of surgeon- scientists and scientists with expertise in research fundamentals essential to clinically driven frontline 'bench to bedside to public policy' programs in treatment of vascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007734-23
Application #
9054149
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
1997-07-01
Project End
2019-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
23
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
Deery, Sarah E; O'Donnell, Thomas F X; Zettervall, Sara L et al. (2018) Use of an Assistant Surgeon Does not Mitigate the Effect of Lead Surgeon Volume on Outcomes Following Open Repair of Intact Abdominal Aortic Aneurysms. Eur J Vasc Endovasc Surg 55:714-719
Liang, Patric; Soden, Peter A; Zettervall, Sara L et al. (2018) Treatment outcomes in diabetic patients with chronic limb-threatening ischemia. J Vasc Surg 68:487-494
Shean, Katie E; Zettervall, Sara L; Deery, Sarah E et al. (2018) Fewer Complications in the Obese Following Lower Extremity Endovascular Interventions. Ann Vasc Surg 49:17-23
Buck, Dominique B; Soden, Peter A; Deery, Sarah E et al. (2018) Comparison of Endovascular Stent Grafts for Abdominal Aortic Aneurysm Repair in Medicare Beneficiaries. Ann Vasc Surg 47:31-42
O'Donnell, Thomas F X; Schermerhorn, Marc L; Liang, Patric et al. (2018) Weekend Effect in Carotid Endarterectomy. Stroke 49:2945-2952
Baker, Meredith A; Nandivada, Prathima; Mitchell, Paul D et al. (2018) Pretreatment with intravenous fish oil reduces hepatic ischemia reperfusion injury in a murine model. Surgery 163:1035-1039
Anez-Bustillos, Lorenzo; Dao, Duy T; Fell, Gillian L et al. (2018) Redefining essential fatty acids in the era of novel intravenous lipid emulsions. Clin Nutr 37:784-789
Servais, Andrew B; Valenzuela, Cristian D; Kienzle, Arne et al. (2018) Functional Mechanics of a Pectin-Based Pleural Sealant after Lung Injury. Tissue Eng Part A 24:695-702
Pothof, Alexander B; Zwanenburg, Emma S; Deery, Sarah E et al. (2018) An update on the incidence of perioperative outcomes after carotid endarterectomy, stratified by type of preprocedural neurologic symptom. J Vasc Surg 67:785-792
Bodewes, Thomas C F; Darling, Jeremy D; Deery, Sarah E et al. (2018) Patient selection and perioperative outcomes of bypass and endovascular intervention as first revascularization strategy for infrainguinal arterial disease. J Vasc Surg 67:206-216.e2

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