This program provides two years of basic science or outcomes research training in fields related to vascular surgery for developing academic clinicians and scientists. It addresses the critical need for adequate research training opportunities for vascular surgeons during their formative years. Research training in bioinformatics, molecular and cell biology, biomechanics, coagulation disorders, angiogenesis, and advanced outcomes research is provided with a focus on clinically relevant problems such as atherogenesis, intimal hyperplasia, prosthetic-host interactions, and pathologic thrombosis. Trainees pursue a program of intense investigation supplemented with course work in research design and statistics. The program is conducted and closely supervised by its directors, co-directors and mentors, all of whom have well-established records of peer- reviewed research, and who were selected both for their current research activities and their proven commitment to training research fellows. For each trainee, individual mentors are chosen from the program's faculty on the basis of their background and research interests. Trainees carry out their own projects under the close guidance of their mentor. Collaboration between laboratories and sharing of expertise is encouraged and fostered through multiple joint activities. Laboratory training can be supplemented by graduate level course work at Harvard Medical School?s Department of Health Care Policy and Research and with Harvard's Faculty of Arts and Sciences. Upon completion of the program, trainees are capable of independent research and possess the scientific and investigative background needed to obtain competitive peer-reviewed funding. In addition, graduates of the program have gained sufficient knowledge and skills necessary to provide translational expertise as they join medical school faculties. Selection of the eight trainees is based on their abilities in research and their desire to pursue an academic career that involves basic or clinical investigation. Applicants are resident physicians who have completed two to five years of post-graduate surgical training, or those who have a PhD with zero to five years of postdoctoral experience. Trainees are required to commit to two years of training. Only those applicants with clearly stated career goals of becoming surgeon-scientists or scientists, and with a keen interest in basic or outcomes research in fields related to vascular surgery are eligible. Candidates wishing to pursue this 2-year research fellowship during clinical training must provide evidence that they will be accepted back into their program upon completion.

Public Health Relevance

Vascular Surgeon-scientists guide research and provide practical ?hands on? perspectives on the biology of vascular diseases and the relevant problems and limitations of devices and interventions on blood vessels. This T32 program is designed to create a cadre of surgeon-scientists and scientists with expertise in research fundamentals essential to clinically driven, frontline ?bench-to-bedside to public policy? programs in treatment of vascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007734-27
Application #
9894844
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Huang, Li-Shin
Project Start
1997-07-01
Project End
2024-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
27
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
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Deery, Sarah E; O'Donnell, Thomas F X; Bodewes, Thomas C F et al. (2018) Early reintervention after open and endovascular abdominal aortic aneurysm repair is associated with high mortality. J Vasc Surg 67:433-440.e1
Zettervall, Sara L; Marshall, Andre P; Fleser, Paul et al. (2018) Association of arterial calcification with chronic limb ischemia in patients with peripheral artery disease. J Vasc Surg 67:507-513
Dao, Duy T; Nandivada, Prathima; Vuong, Jacqueline T et al. (2018) Vascular endothelial growth factor accelerates compensatory lung growth by increasing the alveolar units. Pediatr Res 83:1182-1189
Darling, Jeremy D; Bodewes, Thomas C F; Deery, Sarah E et al. (2018) Outcomes after first-time lower extremity revascularization for chronic limb-threatening ischemia between patients with and without diabetes. J Vasc Surg 67:1159-1169
Pothof, Alexander B; Soden, Peter A; Deery, Sarah E et al. (2018) The impact of race on outcomes after carotid endarterectomy in the United States. J Vasc Surg 68:426-435
Dao, Duy T; Vuong, Jacqueline T; Anez-Bustillos, Lorenzo et al. (2018) Intranasal delivery of VEGF enhances compensatory lung growth in mice. PLoS One 13:e0198700
Deery, Sarah E; Shean, Katie E; Pothof, Alexander B et al. (2018) Three-Year Results of the Endurant Stent Graft System Post Approval Study. Ann Vasc Surg 50:202-208
O'Donnell, Thomas F X; Powell, Chloe; Deery, Sarah E et al. (2018) Regional variation in racial disparities among patients with peripheral artery disease. J Vasc Surg 68:519-526
Deery, Sarah E; O'Donnell, Thomas F X; Shean, Katie E et al. (2018) Racial disparities in outcomes after intact abdominal aortic aneurysm repair. J Vasc Surg 67:1059-1067

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