Abstract

Cardiovascular, pulmonary, hematological diseases (including sickle cell) and cancer account for most of all deaths in this country especially among African-Americans. Pre-doctoral education and training in biomedical sciences with emphasis in biochemical approaches to studying human cardiovascular, hematological and pulmonary diseases is very crucial for the advancement of the goals of the NHLBI. In the past 20 years there has been significant increase in the number of underrepresented minorities who have pursed advanced degrees in biochemical and behavioral sciences. However, their representation in these fields remains low. Therefore, we firmly support the goals of NHLBI to change this trend. A strong PhD. education in biochemistry will prepare students for career development in various areas of biomedical research specially in the diseases, relevant to the goals of NHLBI. In the US, only 2 % of PhD degrees in biochemistry are awarded to African-Americans. The biochemistry department of Meharry Medical College plays a significant role in educating and awarding African-Americans with Biochemistry Ph.D degrees. This year, we awarded 5 African-Americans with Ph.D degrees in Biochemistry, surpassing our goals. This competing application seeks to continue this excellent work by recruiting, training and awarding at least seven highly qualified minority students with Biochemistry Ph.D degrees. Our devoted and enthusiastic Meharry Medical College and Vanderbilt graduate faculty will provide them with excellent multi-disciplinary-based Ph.D education in Biochemistry through formal course work, seminars, workshops, scientific meetings, research training and effective mentoring. Our program will ensure the students of excellent academic and research training in various areas of biomedical sciences pertinent to the goals of NHLBI. By accomplishing this goal, we will contribute significantly towards development of minorities relevant to their research career goals in areas of pathogenesis and control of diseases of the cardiovascular, pulmonary and hematological systems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007735-14
Application #
7460787
Study Section
Special Emphasis Panel (ZHL1-CSR-B (F2))
Program Officer
Chang, Henry
Project Start
1992-07-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
14
Fiscal Year
2008
Total Cost
$215,707
Indirect Cost

  Institution

Name
Meharry Medical College
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208

  Publications

Huderson, Ashley C; Rekha Devi, P V; Niaz, Mohammad S et al. (2018) Alteration of benzo(a)pyrene biotransformation by resveratrol in Apc Min/+ mouse model of colon carcinogenesis. Invest New Drugs :
Pulliam, Stephanie R; Pellom Jr, Samuel T; Shanker, Anil et al. (2016) Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine 84:74-87
Banks, Leah D; Amoah, Priscilla; Niaz, Mohammad S et al. (2016) Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model. J Nutr Biochem 28:37-50
Swepson, Chelsie; Ranjan, Alok; Balasubramaniam, Muthukumar et al. (2016) Cocaine Enhances HIV-1 Transcription in Macrophages by Inducing p38 MAPK Phosphorylation. Front Microbiol 7:823
Harris, Kelly L; Pulliam, Stephanie R; Okoro, Emmanuel et al. (2016) Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget 7:28947-60
Pulliam, Stephanie R; Uzhachenko, Roman V; Adunyah, Samuel E et al. (2016) Common gamma chain cytokines in combinatorial immune strategies against cancer. Immunol Lett 169:61-72
Booker, Burthia E; Clark, Ryan S; Pellom, Samuel T et al. (2015) Interleukin-34 induces monocytic-like differentiation in leukemia cell lines. Int J Biochem Mol Biol 6:1-16
Dash, Sabyasachi; Balasubramaniam, Muthukumar; Villalta, Fernando et al. (2015) Impact of cocaine abuse on HIV pathogenesis. Front Microbiol 6:1111
Pandhare, Jui; Addai, Amma B; Mantri, Chinmay K et al. (2014) Cocaine enhances HIV-1-induced CD4(+) T-cell apoptosis: implications in disease progression in cocaine-abusing HIV-1 patients. Am J Pathol 184:927-936
Thompson, Pamela D; Sakwe, Amos; Koumangoye, Rainelli et al. (2014) Alpha-2 Heremans Schmid Glycoprotein (AHSG) modulates signaling pathways in head and neck squamous cell carcinoma cell line SQ20B. Exp Cell Res 321:123-32

Showing the most recent 10 out of 36 publications