This proposal is the third competing renewal of our Training Grant in Lung Science. During the last 8 and a half years, the Training Grant has provided 47 trainees the opportunity to develop strong foundations in lung science, including 25 MDs, 8 PhDs and 14 Predoctoral graduate students (with 1 MD-PhD student). Of the 21 MD trainees completing training over the past 10 years, 13 accepted academic positions, all of whom remain in academic positions and to date X have successfully competed for NIH and other funding. Of the 8 post-doctoral and 14 pre-doctoral PhD trainees, most are still in training positions, but four hold faculty positions. There are three major aims of our Training Program: (1) to provide 3 years of rigorous scientific training for physician-scientists, enabling them to become independent investigators examining scientific questions related to human lung disease;(2) to provide up to 3 years of post-doctoral training to PhD scientists focusing their studies in lung biology and promoting long term careers in this field;and (3) to train graduate students from the MD-PhD program and other established degree-granting programs - and guide them into careers in lung research. MD trainees are strongly encouraged to obtain an advanced degree in order to optimize their opportunities for a successful investigative career. The major curricular areas encompassed by the program are: (1) Cell &Molecular Biology;(2) Systems Biology, Bioengineering;&Bio-Informatics;and (3) Clinical Research, leading to a Masters in Public Health or Clinical Research. The curriculum provides formal training and degree opportunities in Biochemistry, Molecular Biology &Biochemistry (BMBB Department);Genetics, Cell Biology &Development (GCD Department);Immunology;Cancer Biology (MiCaB program);Bioengineering (Minor program);Bioinformatics (Masters program);Masters in Public Health;and Masters in Clinical Research. The training faculty is drawn from 4 colleges in our Academic Health Center and the Institute of Technology. Faculty expertise extends across a broad spectrum of areas, including: pulmonary fibrosis;lung injury;lung cancer;COPD;sleep medicine;asthma;cystic fibrosis;and bioethics. Comprehensive resources and stable research funding in each area provide an outstanding training environment.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Colombini-Hatch, Sandra
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University of Minnesota Twin Cities
Internal Medicine/Medicine
Schools of Medicine
United States
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Truong, Thu H; Lange, Carol A (2018) Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers. Endocrinology 159:3897-3907
Skolasinski, Steven; Panoskaltsis-Mortari, Angela (2018) Decellularization of Intact Lung Tissue Through Vasculature and Airways Using Negative and Positive Pressure. Methods Mol Biol 1577:307-315
Murie, Carl; Sandri, Brian; Sandberg, Ann-Sofi et al. (2018) Normalization of mass spectrometry data (NOMAD). Adv Biol Regul 67:128-133
Waring, Barbara M; Sjaastad, Louisa E; Fiege, Jessica K et al. (2018) MicroRNA-Based Attenuation of Influenza Virus across Susceptible Hosts. J Virol 92:
Osborn, John W; Banek, Christopher T (2018) Catheter-Based Renal Nerve Ablation as a Novel Hypertension Therapy: Lost, and Then Found, in Translation. Hypertension 71:383-388
Guo, Liang; Sharma, Suresh D; Debes, Jose et al. (2018) The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts. Nucleic Acids Res 46:2537-2547
Truong, Thu H; Hu, Hsiangyu; Temiz, Nuri A et al. (2018) Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes. Mol Cancer Res 16:707-719
Simones, Ann A; Beisang, Daniel J; Panoskaltsis-Mortari, Angela et al. (2018) Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: a clinical review. Pediatr Res 83:308-317
Herrera, Jeremy; Beisang, Daniel J; Peterson, Mark et al. (2018) Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis. Am J Respir Crit Care Med 198:486-496
Sjaastad, Louisa E; Fay, Elizabeth J; Fiege, Jessica K et al. (2018) Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo. Proc Natl Acad Sci U S A 115:9610-9615

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