The purpose of this training program is to prepare M.D., M.D./Ph.D. postdoctoral fellows for research careers in the multi-disciplinary field of Transfusion Medicine (TM). Fellows will conduct independent research in the laboratory of an experienced mentor, selected among faculty with diverse interests including cell membrane (red blood cells, platelets) structure and function, immunobiology of autoimmune and neoplastic disorders, hematopoiesis and virology. The 13 mentors selected for this program include 10 senior scientists with extensive experience training both predoctoral and postdoctoral fellows, and with current, active, interlaboratory collaborations. The uniqueness of this training program lies in the availability of a broad-based research environment coupled with a well established clinical TM fellowship training program. This provides fellows with the opportunity to pursue focused research training or to incorporate clinical TM fellowship training depending upon their previous educational experience. During the first 4 years of training grant support (1994 to present), 9 fellows have successfully completed the program, some acquiring research funding (e.g. KO8) or establishing permanent positions with research responsibilities as TM junior faculty or research scientists.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007775-06
Application #
2799802
Study Section
Special Emphasis Panel (ZHL1-CSR-K (F1))
Project Start
1993-07-01
Project End
2004-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hotz, Meghan J; Qing, Danielle; Shashaty, Michael G S et al. (2018) Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury. Am J Respir Crit Care Med 197:470-480
Villa, Carlos H; Porturas, Thomas; Sell, Mary et al. (2018) Rapid prediction of stem cell mobilization using volume and conductivity data from automated hematology analyzers. Transfusion 58:330-338
Villa, Carlos H; Pan, Daniel C; Johnston, Ian H et al. (2018) Biocompatible coupling of therapeutic fusion proteins to human erythrocytes. Blood Adv 2:165-176
Greineder, Colin F; Johnston, Ian H; Villa, Carlos H et al. (2017) ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model. Blood Adv 1:1452-1465
Carnemolla, Ronald; Villa, Carlos H; Greineder, Colin F et al. (2017) Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury. FASEB J 31:761-770
Villa, Carlos H; Cines, Douglas B; Siegel, Don L et al. (2017) Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond. Transfus Med Rev 31:26-35
Brenner, Jacob S; Bhamidipati, Kartik; Glassman, Patrick M et al. (2017) Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions. Nanomedicine 13:1495-1506
Fesnak, Andrew D; Hanley, Patrick J; Levine, Bruce L (2017) Considerations in T Cell Therapy Product Development for B Cell Leukemia and Lymphoma Immunotherapy. Curr Hematol Malig Rep 12:335-343
Levine, Bruce L; Fesnak, Andrew D; Riviere, Isabelle (2017) Showcasing Clinical Development and Production of Cellular Therapies. Mol Ther 25:827-828
Kiseleva, Raisa; Greineder, Colin F; Villa, Carlos H et al. (2017) Mechanism of Collaborative Enhancement of Binding of Paired Antibodies to Distinct Epitopes of Platelet Endothelial Cell Adhesion Molecule-1. PLoS One 12:e0169537

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