Abstract

The purpose of this program is to train scientists for careers in hematological research. The primary focus is on the cellular physiology of the hematopoietic, immune and hemostatic systems, but extends to related areas of developmental and cellular hematology, leukemia pathogenesis, hematopoietic development, cellular biology of iron metabolism, viral pathogenesis, cell growth signaling, genomic instability, and experimental therapeutics. The program is administered through the Divisions of Molecular Medicine and Hematology and Medical Oncology, which constitute the major laboratory research areas of the Department of Internal Medicine, and includes other Departmental units within OHSU that participate in the large and interactive Oregon Cancer Institute. The training faculty consists of 26 members from Departments of Medicine, Pediatrics, Microbiology and Immunology, Biochemistry and Molecular Biology, Cell and Developmental Biology and the Vollum Institute. Training in translational research is closely allied with clinical activities of the OHSU University Hospital, Portland VA Medical Center and the Center for Hematologic Malignancies, which specializes in bone marrow transplantation and leukemia management. The increasing number of clinician scientists and basic scientists in hematology at OHSU provides an outstanding environment for our graduate and postgraduate trainees.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007781-15
Application #
7242547
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Chang, Henry
Project Start
1993-07-01
Project End
2008-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
15
Fiscal Year
2007
Total Cost
$336,349
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Gast, Charles E; Silk, Alain D; Zarour, Luai et al. (2018) Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival. Sci Adv 4:eaat7828
Van Hook, Kathryn; Wang, Zhiping; Chen, Dexi et al. (2017) ?N-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival. Biochem Biophys Res Commun 482:1271-1277
Kamimae-Lanning, Ashley N; Krasnow, Stephanie M; Goloviznina, Natalya A et al. (2015) Maternal high-fat diet and obesity compromise fetal hematopoiesis. Mol Metab 4:25-38
Maxson, Julia E; Luty, Samuel B; MacManiman, Jason D et al. (2014) Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization. J Biol Chem 289:5820-7
Owen, Nichole; Hejna, James; Rennie, Scott et al. (2014) Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM. Cytogenet Genome Res 144:255-263
Maxson, Julia E; Gotlib, Jason; Pollyea, Daniel A et al. (2013) Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med 368:1781-90
Aslan, J E; McCarty, O J T (2013) Rho GTPases in platelet function. J Thromb Haemost 11:35-46
Farrington, Lila A; Smith, Tameka A; Grey, Finn et al. (2013) Competition for antigen at the level of the APC is a major determinant of immunodominance during memory inflation in murine cytomegalovirus infection. J Immunol 190:3410-6
Zachman, Derek K; Leon, Ronald P; Das, Prerna et al. (2013) Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury. Stem Cell Res 11:1013-21
Garbati, Michael R; Hays, Laura E; Keeble, Winifred et al. (2013) FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1* in macrophages. Blood 122:3197-205

Showing the most recent 10 out of 56 publications