This is a competitive renewal of a T32 training grant at the University of Colorado to support the training of post-doctoral fellows (MD and PhD) who wish to prepare for careers in cardiovascular research. The broad objective of this training program is to create a training environment that will provide the next generation of cardiovascular researchers with an appreciation of the linked research goals of the NIH/NHLBI strategic plan: To understand the molecular and physiologic basis of cardiovascular health and disease; To develop personalized preventive and therapeutic regimens for organ specific diseases and To generate an improved understanding of the processes involved in translating research into practice. To meet this objective, we have developed a comprehensive training plan and we have assembled a group of mentors from the rich cardiovascular research community at the University of Colorado campuses in Denver and Boulder. The specific goals of the training program are: To assemble a group of established and junior scientists with a shared commitment to the training of the next generation of cardiovascular investigators. Focus areas of investigation subserved by the trainers is consistent with the NIH/NHLBI strategic plan and includes faculty with an interest in basic biology of the cardiac myocyte and the vasculature;integrative and human physiology;and health services and outcomes research. To implement a recruitment strategy that will allow us to attract top MD, MD-PhD, and PhD candidates, including graduates of our clinical and basic science training programs, in order to provide them with cross disciplinary training in cardiovascular research that will prepare them for future academic careers. To develop a program of didactics and a multi-tiered mentoring process designed specifically for trainees supported by this grant that includes: topics in cardiovascular science;a hands-on mini- course focused on cardiovascular imaging and integrated physiology;participation in degree granting programs (PhD and/or MSPH) in both Health Services Research and Health Information Technology;and a mentoring program that will provide trainees with on-going scientific mentorship and career guidance

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Commarato, Michael
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University of Colorado Denver
Internal Medicine/Medicine
Schools of Medicine
United States
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Awad, Fawaz; Assrawi, Eman; Louvrier, Camille et al. (2018) Inflammasome biology, molecular pathology and therapeutic implications. Pharmacol Ther 187:133-149
Leary, Peter J; Kronmal, Richard A; Bluemke, David A et al. (2018) Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). Am J Cardiol 121:256-261
Levy, Andrew E; Huang, Carrie; Huang, Allen et al. (2018) Recent Approaches to Improve Medication Adherence in Patients with Coronary Heart Disease: Progress Towards a Learning Healthcare System. Curr Atheroscler Rep 20:5
Levy, Andrew E; Shah, Nishant R; Matheny, Michael E et al. (2018) Determining post-test risk in a national sample of stress nuclear myocardial perfusion imaging reports: Implications for natural language processing tools. J Nucl Cardiol :
Francisco, Michael A; Brunt, Vienna E; Jensen, Krista Nicole et al. (2017) Ten days of repeated local forearm heating does not affect cutaneous vascular function. J Appl Physiol (1985) 123:310-316
Armstrong, Ehrin J; Graham, Laura; Waldo, Stephen W et al. (2017) Patient and lesion-specific characteristics predict risk of major adverse cardiovascular events among patients with previous percutaneous coronary intervention undergoing noncardiac surgery. Catheter Cardiovasc Interv 89:617-627
Valle, Javier A; Kaltenbach, Lisa A; Bradley, Steven M et al. (2017) Variation in the Adoption of Transradial Access for ST-Segment Elevation Myocardial Infarction: Insights From the NCDR CathPCI Registry. JACC Cardiovasc Interv 10:2242-2254
Blakeslee, Weston W; Lin, Ying-Hsi; Stratton, Matthew S et al. (2017) Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes. J Mol Cell Cardiol 112:74-82
Bradley, Steven M; Hess, Gregory P; Stewart, Patrick et al. (2017) Implications of the PEGASUS-TIMI 54 trial for US clinical practice. Open Heart 4:e000580
Valle, Javier A; Armstrong, Ehrin J; Waldo, Stephen W (2017) Orbital Atherectomy in the Renal Artery: A New Frontier for an Emerging Technology? J Invasive Cardiol 29:E10-E12

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