Abstract

The purpose of this application is to continue a training program devoted to the study of the molecular and cellular basis of cardiovascular diseases and to the development of novel therapeutic approaches to these diseases. Our proposal builds on a strong tradition of cardiovascular research and clinical training at the University of Washington School of Medicine. This renewal application is more specifically focused on four areas of opportunity with the broader field of cardiovascular disease research: (1) Signaling and Vascular Injury; (2) Gene and Cell Therapy; (3) Genetics of Cardiovascular Risk; and (4) Biomechanics and Bioengineering. These are all areas of established strength at the University of Washington School of Medicine. This program is the major source of support for clinical fellows in Cardiology, Cardiovascular Pathology, and Vascular and Cardiothoracic Surgery who wish to spend a substantial portion of their training time acquiring the skills that are required to succeed as independent, laboratory-based principal investigators. The program also provides support for trainees with Ph.D. degrees who wish to pursue training in laboratories that have a significant focus on molecular and cellular biology and genetics of the mammalian cardiovascular system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007828-07
Application #
6622767
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Schucker, Beth
Project Start
1997-07-01
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
7
Fiscal Year
2003
Total Cost
$511,969
Indirect Cost

  Institution

Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Konkle, B A; Johnsen, J M; Wheeler, M et al. (2018) Genotypes, phenotypes and whole genome sequence: Approaches from the My Life Our Future haemophilia project. Haemophilia 24 Suppl 6:87-94
Lee, Seung-Been; Wheeler, Marsha M; Patterson, Karynne et al. (2018) Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model. Genet Med :
Mikheev, Andrei M; Mikheeva, Svetlana A; Severs, Liza J et al. (2018) Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma. Mol Oncol 12:1188-1202
Moccia, Amanda; Srivastava, Anshika; Skidmore, Jennifer M et al. (2018) Genetic analysis of CHARGE syndrome identifies overlapping molecular biology. Genet Med 20:1022-1029
Wacker, Bradley K; Dronadula, Nagadhara; Bi, Lianxiang et al. (2018) Apo A-I (Apolipoprotein A-I) Vascular Gene Therapy Provides Durable Protection Against Atherosclerosis in Hyperlipidemic Rabbits. Arterioscler Thromb Vasc Biol 38:206-217
Wheeler, Marsha M; Lannert, Kerry W; Huston, Haley et al. (2018) Genomic characterization of the RH locus detects complex and novel structural variation in multi-ethnic cohorts. Genet Med :
Cusanovich, Darren A; Hill, Andrew J; Aghamirzaie, Delasa et al. (2018) A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility. Cell 174:1309-1324.e18
Wallingford, Mary C; Benson, Ciara; Chavkin, Nicholas W et al. (2018) Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone. Front Physiol 9:1044
Walker, Matthew A; Tian, Rong (2018) Raising NAD in Heart Failure: Time to Translate? Circulation 137:2274-2277
Cao, Junyue; Cusanovich, Darren A; Ramani, Vijay et al. (2018) Joint profiling of chromatin accessibility and gene expression in thousands of single cells. Science 361:1380-1385

Showing the most recent 10 out of 154 publications