Abstract

The purpose of this application is to continue a training program devoted to the study of the molecular and cellular basis of cardiovascular diseases and to the development of novel therapeutic approaches to these diseases. Our proposal builds on a strong tradition of cardiovascular research and clinical training at the University of Washington School of Medicine. This renewal application is more specifically focused on four areas of opportunity with the broader field of cardiovascular disease research: (1) Signaling and Vascular Injury;(2) Gene and Cell Therapy;(3) Genetics of Cardiovascular Risk;and (4) Biomechanics, Bioengineering, and Cardiovascular Imaging. These are all areas of established strength at the University of Washington School of Medicine. This program is the major source of support for clinical fellows in Cardiology, Cardiovascular Pathology, and Vascular and Cardiothoracic Surgery who wish to spend a substantial portion of their training time acquiring the skills that are required to succeed as independent, laboratory-based principal investigators. The program also provides support for trainees with Ph.D. degrees who wish to pursue training in laboratories that have a significant focus on molecular and cellular biology and genetics of the mammalian cardiovascular system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007828-15
Application #
8081023
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Roltsch, Mark
Project Start
1997-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
15
Fiscal Year
2011
Total Cost
$322,867
Indirect Cost

  Institution

Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Wacker, Bradley K; Dronadula, Nagadhara; Bi, Lianxiang et al. (2018) Apo A-I (Apolipoprotein A-I) Vascular Gene Therapy Provides Durable Protection Against Atherosclerosis in Hyperlipidemic Rabbits. Arterioscler Thromb Vasc Biol 38:206-217
Wheeler, Marsha M; Lannert, Kerry W; Huston, Haley et al. (2018) Genomic characterization of the RH locus detects complex and novel structural variation in multi-ethnic cohorts. Genet Med :
Cusanovich, Darren A; Hill, Andrew J; Aghamirzaie, Delasa et al. (2018) A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility. Cell 174:1309-1324.e18
Wallingford, Mary C; Benson, Ciara; Chavkin, Nicholas W et al. (2018) Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone. Front Physiol 9:1044
Walker, Matthew A; Tian, Rong (2018) Raising NAD in Heart Failure: Time to Translate? Circulation 137:2274-2277
Cao, Junyue; Cusanovich, Darren A; Ramani, Vijay et al. (2018) Joint profiling of chromatin accessibility and gene expression in thousands of single cells. Science 361:1380-1385
Hill, Andrew J; McFaline-Figueroa, José L; Starita, Lea M et al. (2018) On the design of CRISPR-based single-cell molecular screens. Nat Methods 15:271-274
Cusanovich, Darren A; Reddington, James P; Garfield, David A et al. (2018) The cis-regulatory dynamics of embryonic development at single-cell resolution. Nature 555:538-542
Konkle, B A; Johnsen, J M; Wheeler, M et al. (2018) Genotypes, phenotypes and whole genome sequence: Approaches from the My Life Our Future haemophilia project. Haemophilia 24 Suppl 6:87-94
Lee, Seung-Been; Wheeler, Marsha M; Patterson, Karynne et al. (2018) Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model. Genet Med :

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