This T32 renewal application for yrs to 22-26 seeks continuing support for our highly successful Lung Biology and Pathobiology Training Program at The University of Illinois College of Medicine, Chicago. The singular and concentrated emphasis of the Program continues to be to mentor, at a scientifically advanced level, a predoctoral (post-baccalaureate) and postdoctoral trainee cohort of new lung researchers as they develop into independent scientists with careers in academia, biopharmaceutical industry, or take advantage of a variety of newly evolving opportunities. Although the number of trainees is held constant and the dominant effort is in research training, the program is being expanded to include exposure to scientific research-related careers such as policymaking, teaching, administration, and journalism. The Program has a strong record of developing careers of outstanding scientists and promoting skills in critical scientific thinking and problem- solving. In addition t the cohort of stellar current preceptors, we have on the basis of targeted recent recruitments integrated new faculty members who bring exciting new perspectives. The Program provides in- depth multi- and cross-disciplinary research training where a seamless transition from basic to translational/clinical research projects is feasible and encouraged. The Program is designed to provide mentoring by a primary mentor however, based on specifics of the research project, a secondary mentor will participate as an equal partner. Once in the Program, the first order of business will be for the trainees will be to formulate an Individual Development Plan, with their mentor(s)' guidance. This will provide a road-map as the trainees mature by acquiring essential skills as they move towards greater independence. Each trainee's progress will be carefully and creatively monitored throughout training by their Trainee Advisory Committee, the Extramural Lung Seminar Series, and other less structured forums designed to promote dialog and interactions. The key activities of the Program include the Extramural Lung Seminar Series given by scientific leaders, Annual Retreat, Career Symposium, and a mandatory specifically designed Lung Biology Course. This application requests continued funding for 6 predoctoral and 6 postdoctoral trainees. The Program is grounded in 4 inter-related thematic areas of research training: (1) Lung Vascular Injury and Repair, (2) Stem Cells and Lung Regeneration and Repair, (3) Cellular and Humoral Bases of Lung Inflammation and Injury, and (4) Cell Signaling Mechanisms in Lung. We are poised with continued vigor to nurture and train a highly-qualified group of nascent scientists in an inspired, comprehensive environment in areas of lung- related research and areas that intersect with lung biology and pathobiology for careers in academia, research institutions, biopharmaceutical industry, and other burgeoning areas.
This training grant application focused on lung research requests continuing support for 6 predoctoral and 6 postdoctoral trainees. The Training Program is grounded in 4 inter-related thematic areas of research training: (1) Lung Vascular Injury and Repair, (2) Stem Cells and Lung Regeneration and Repair, (3) Cellular and Humoral Bases of Lung Inflammation and Injury, and (4) Cell Signaling Mechanisms in Lung. We think we are very well positioned to train a highly-qualified group of young scientists in an inspired, comprehensive environment. Scientific training is offered in areas of lung-related research and areas that intersect with lung biology and pathobiology. We will prepare the trainees for careers in academia, research institutions, biopharmaceutical industry, and other burgeoning areas.
|Di, Anke; Xiong, Shiqin; Ye, Zhiming et al. (2018) The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation. Immunity 49:56-65.e4|
|Le Master, Elizabeth; Huang, Ru-Ting; Zhang, Chongxu et al. (2018) Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins. Arterioscler Thromb Vasc Biol 38:64-75|
|Cheng, Kwong Tai; Xiong, Shiqin; Ye, Zhiming et al. (2017) Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest 127:4124-4135|
|Baruah, Jugajyoti; Hitzman, Ryan; Zhang, Jane et al. (2017) The allosteric glycogen synthase kinase-3 inhibitor NP12 limits myocardial remodeling and promotes angiogenesis in an acute myocardial infarction model. J Biol Chem 292:20785-20798|
|Tsang, Kit Man; Hyun, James S; Cheng, Kwong Tai et al. (2017) Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1?. Stem Cell Reports 9:796-806|
|Wary, Anita; Wary, Neil; Baruah, Jugajyoti et al. (2017) Chromatin-modifying agents convert fibroblasts to OCT4+ and VEGFR-2+ capillary tube-forming cells. PLoS One 12:e0176496|
|Yamada, Kaori H; Kang, Hojin; Malik, Asrar B (2017) Antiangiogenic Therapeutic Potential of Peptides Derived from the Molecular Motor KIF13B that Transports VEGFR2 to Plasmalemma in Endothelial Cells. Am J Pathol 187:214-224|
|Rexius-Hall, Megan L; Rehman, Jalees; Eddington, David T (2017) A microfluidic oxygen gradient demonstrates differential activation of the hypoxia-regulated transcription factors HIF-1? and HIF-2?. Integr Biol (Camb) 9:742-750|
|Zhang, Lianghui; Jambusaria, Ankit; Hong, Zhigang et al. (2017) SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+Progenitor Cells. Circulation 135:2505-2523|
|Yazbeck, Pascal; Tauseef, Mohammad; Kruse, Kevin et al. (2017) STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry. Sci Rep 7:42758|
Showing the most recent 10 out of 79 publications