This application is a competitive renewal for a multidisciplinary training program in cardiovascular disease. Its goal is to provide training in boh basic and clinical sciences relevant to the study of cardiovascular disease. This program proposes to support eight MD or PhD postdoctoral fellows per year. The training program will consist of a two-to-three year experience in the laboratory under the close supervision of a faculty mentor. These experiences will include molecular and cellular biology, biochemistry, physiology, epidemiology, or healthcare outcomes related to cardiovascular disease. The program utilizes faculty mentors from the Departments of Internal Medicine, (Divisions of Cardiovascular Disease, Pulmonary and Critical Care Medicine, Nephrology, Endocrinology, Metabolism and Diabetes, General Medicine, and Molecular Medicine) Pathology, Pharmacology, Integrative Physiology, Biological Chemistry, Kinesiology, Neurology, Pediatric Pulmonary Medicine and Vascular Surgery. All mentors have extensive research experience in a particular discipline and most have been involved in the training of postdoctoral fellows who have subsequently gone on to independent, productive careers in research and/or teaching. New faculty members have been incorporated into the program to extend the outstanding training opportunities in biological sciences and disciplines relevant to clinical research. The state of the art $250,000,000 comprehensive cardiovascular center completed in 2007 was accompanied by growth of the cardiovascular related faculty and available resources. A cardiovascular research facilities recently established at the North Campus Research Complex, including approximately 40,000 square feet of laboratory space, will allow further centralization and expansion of scientists involved in cardiovascular research. This training program will continue to provide a structured curriculum that contains appropriate course work, exposure to lecture series, and in-depth laboratory and/or clinical research experience. A broad range of research topics are available to trainees, including pathophysiology of atherosclerosis, thrombosis, protease biology, mechanisms of fibrosis, obesity and metabolism, mechanisms of myocardial cellular function, molecular genetics, outcomes in cardiovascular disease, quality improvement, physician decision making, and economic assessment of cardiovascular interventions. Continuation of this training grant in cardiovascular disease at the University of Michigan will capitalize on the existing and growing resources that have been assembled at this institution. The program is designed to produce the next generation of highly trained investigators devoted to understanding the pathogenesis and treatment of cardiovascular disease.

Public Health Relevance

Cardiovascular disease remains the leading cause of mortality in the United States. However, age-adjusted mortality rates due to cardiovascular events have been progressively declining due to scientific breakthroughs in prevention and treatment strategies. For this progress to continue, it is critical that we aggressively recruit and train the next generation of cardiovascular investigators. This proposal represents a diverse training program across a broad spectrum of cardiovascular diseases.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Huang, Li-Shin
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University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
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Ward, Sarah T; Dimick, Justin B; Zhang, Wenying et al. (2018) Association Between Hospital Staffing Models and Failure to Rescue. Ann Surg :
Narang, Akhil; Velagapudi, Poonam; Rajagopalan, Bharath et al. (2018) A New Educational Framework to Improve Lifelong Learning for Cardiologists. J Am Coll Cardiol 71:454-462
Alyesh, Daniel M; Seth, Milan; Miller, David C et al. (2018) Exploring the Healthcare Value of Percutaneous Coronary Intervention: Appropriateness, Outcomes, and Costs in Michigan Hospitals. Circ Cardiovasc Qual Outcomes 11:e004328
Frasier, Chad R; Zhang, Helen; Offord, James et al. (2018) Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes. Stem Cell Reports 11:626-634
Sukul, Devraj; Bhatt, Deepak L; Seth, Milan et al. (2018) Appropriateness and Outcomes of Percutaneous Coronary Intervention at Top-Ranked and Nonranked Hospitals in the United States. JACC Cardiovasc Interv 11:342-350
Emmer, Brian T; Hesketh, Geoffrey G; Kotnik, Emilee et al. (2018) The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. Elife 7:
Likosky, Donald S; Sukul, Devraj; Seth, Milan et al. (2018) Association Between Medicaid Expansion and Cardiovascular Interventions in Michigan. J Am Coll Cardiol 71:1050-1051
Sinha, Shashank S; Moloci, Nicholas M; Ryan, Andrew M et al. (2018) The Effect of Medicare Accountable Care Organizations on Early and Late Payments for Cardiovascular Disease Episodes. Circ Cardiovasc Qual Outcomes 11:e004495
Liang, Qixing; Ward, Sarah; Pagani, Francis D et al. (2018) Linkage of Medicare Records to the Interagency Registry of Mechanically Assisted Circulatory Support. Ann Thorac Surg 105:1397-1402
Harris, Chelsea A; Banerjee, Tanima; Cramer, Monica et al. (2018) Editorial (Spring) Board? Gender Composition in High-impact General Surgery Journals Over 20 Years. Ann Surg :

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