The training program described in this renewal application represents a new paradigm for training academic cardiologists as cardiovascular scientists, based on the UCLA STAR (Specialty Training and Advanced Research) Program combining clinical subspecialty training with research training leading to a Ph.D. or Masters degree. This program has been in existence here at UCLA for over 13 years and has trained over 15 cardiovascular scientists and researchers. M.D. trainees will complete 2 years of subspecialty cardiology training and 3-4 years of research training that fulfills the requirements for a Ph.D. degree in Public health or one of the~basic sciences or a Masters of Clinical Investigation, including formal course work and research leading to successful thesis defense. M.D./Ph.D. trainees undergo 2 years of post-doctoral research training, including elective course work. Eight positions are requested, to provide support for the research training component only. The training faculty consists of 34 senior preceptors and 15 supporting faculty. Only senior preceptors may serve as primary research mentors, and they come from 5 groups: the UCLA Cardiovascular Research Laboratory, the UCLA Atherosclerosis Research Unit, the UCLA ACCESS Program (a multi-departmental program administering Ph.D. training in life sciences), the School of Engineering, and, for health services research, the UCLA School of Public Health and RAND Graduate School. Supporting faculty do not act as primary mentors, but play a key role in enhancing the overall research environment and fostering translational research from the basic to the clinical arena. The research programs of the faculty are supported by over 39 million dollars in direct costs annually from extramural sources. By integrating cardiology subspecialty training with the formal recruitment of Ph.D. training (or equivalent post-doctoral training for those already having a Ph.D.), the UCLA Cardiology STAR Program provides graduates with the rigorous research background essential to translate the unparalleled advances in molecular health sciences into modern molecular medicine.

Public Health Relevance

i The UCLA Cardiovascular Scientist Program is specifically designed to combine comprehensive research training leading to a Ph.D. degree or equivalent with subspecialty training in clinical cardiology for MDs. The goal of this program is to provide cardiologists with highly competitive research training, allowing them to translate advances in basic research to the clinic, or to address health service issues critical to society.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007895-13
Application #
8076213
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Roltsch, Mark
Project Start
1998-07-01
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
13
Fiscal Year
2011
Total Cost
$331,106
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
West, Brian H; Noureddin, Nabil; Mamzhi, Yakov et al. (2018) Frequency of Patent Foramen Ovale and Migraine in Patients With Cryptogenic Stroke. Stroke 49:1123-1128
Baek, Kyung In; Packard, René R Sevag; Hsu, Jeffrey J et al. (2018) Ultrafine Particle Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antioxid Redox Signal 28:1209-1223
Demer, Linda L; Hsu, Jeffrey J; Tintut, Yin (2018) Steroid Hormone Vitamin D: Implications for Cardiovascular Disease. Circ Res 122:1576-1585
Chella Krishnan, Karthickeyan; Kurt, Zeyneb; Barrere-Cain, Rio et al. (2018) Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst 6:103-115.e7
Erbilgin, Ayca; Seldin, Marcus M; Wu, Xiuju et al. (2018) Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol 38:2016-2027
Do, Duc H; Eyvazian, Vaughn; Bayoneta, Aileen J et al. (2018) Cardiac magnetic resonance imaging using wideband sequences in patients with nonconditional cardiac implanted electronic devices. Heart Rhythm 15:218-225
Messerschmidt, Victoria; Bailey, Zachary; Baek, Kyung In et al. (2018) Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart. J Vis Exp :
Baek, Kyung In; Ding, Yichen; Chang, Chih-Chiang et al. (2018) Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging. Prog Biophys Mol Biol 138:105-115
Ding, Yichen; Ma, Jianguo; Langenbacher, Adam D et al. (2018) Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight 3:
Seldin, Marcus M; Koplev, Simon; Rajbhandari, Prashant et al. (2018) A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. Cell Metab 27:1138-1155.e6

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