The current training program brings together twenty faculty members from a total of nine Departments on campus to focus on two areas of broad importance for hematology and human disease: vascular biology and stem cell biology/hematologic malignancy. The primary goal of this grant is to train a mixture of M.D. and Ph.D. scientists with outstanding potential to develop a sustained, independent research program in these fields. Two predoctoral positions are requested to take advantage of the outstanding pool of M.D.- Ph.D. candidates and the long tradition of strong graduate programs at the University of Wisconsin. Fellows or residents in the Clinical Investigator track from the participating clinical Departments (Medicine, Pediatrics, Pathology, and Surgery) and Ph.D. trainees from the participating basic science departments (Anatomy, Biochemistry, Biostatistics, Microbiology, and Pharmacology) will be selected for the four postdoctoral positions. The faculty are a stable and interactive group that clusters in three major interest groups: basic and clinical aspects of hemostasis/inflammation, hematologic malignancies, and human stem cells/bone marrow transplantation. The faculty have broad expertise in both basic science and clinical sciences, including experimental approaches in gene arrays and genomics, transcriptional and post-transcriptional gene expression, protein structural analysis, proteomics, cell biology, hematopoetic and endothelial cell culture, murine animal models, primate and human embryonic stems cells, and bone marrow transplantation. There is a strong emphasis oh providing the multidisciplinary training required to pursue translational research opportunities, and the formal training of clinical investigators. Our training program takes advantage of the Clinical Investigator Preparatory Program (K30 grant) at the University of Wisconsin to provide didactic training in clinical trial design and biostatistics for candidates pursuing translational research projects. The program has an excellent record of retaining trainees in academic medicine. Of our eight predoctoral candidates, six continue in their Ph.D. degree program, and two have completed their degree and obtained excellent post-doctoral positions at outside institutions (Harvard, Mayo). Eleven of our postdoctoral candidates have now completed their research training. Six are successful academic researchers, two are active researchers in biotechnology companies (including a Director of Research), and one is in medical school. We have successfully recruited four under-represented minorities to the grant, and fully half of our appointees are women. The large pool of qualified candidates, outstanding mentorship abilities of our trainers, excellent core facilities, institutional commitment, and broad range of scientific expertise fosters multidisciplinary approaches that will ensure successful careers in science for our trainees.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007899-13
Application #
7919327
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
1998-07-01
Project End
2013-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
13
Fiscal Year
2010
Total Cost
$252,892
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Hind, Laurel E; Ingram, Patrick N; Beebe, David J et al. (2018) Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P aeruginosa. Blood 132:1818-1828
Lieberman, Nicole A P; DeGolier, Kole; Haberthur, Kristen et al. (2018) An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells. Front Immunol 9:150
Turton, Keren B; Wilkerson, Emily M; Hebert, Alex S et al. (2018) Expression of novel ""LOCGEF"" isoforms of ARHGEF18 in eosinophils. J Leukoc Biol 104:135-145
Hernández-Santos, Nydiaris; Wiesner, Darin L; Fites, J Scott et al. (2018) Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection. Cell Host Microbe 23:511-522.e5
Lu, Li; Zhu, Fen; Zhang, Meili et al. (2018) Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma. Proc Natl Acad Sci U S A 115:E498-E505
Wolfe, Adam D; Capitini, Christian M; Salamat, Shahriar M et al. (2018) Neck Rhabdoid Tumors: Clinical Features and Consideration of Autologous Stem Cell Transplant. J Pediatr Hematol Oncol 40:e50-e54
Reidenbach, Andrew G; Kemmerer, Zachary A; Aydin, Deniz et al. (2018) Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. Cell Chem Biol 25:154-165.e11
Chanakira, Alice; Westmark, Pamela R; Ong, Irene M et al. (2017) Tissue factor-factor VIIa complex triggers protease activated receptor 2-dependent growth factor release and migration in ovarian cancer. Gynecol Oncol 145:167-175
Mosher, Deane F; Wilkerson, Emily M; Turton, Keren B et al. (2017) Proteomics of Eosinophil Activation. Front Med (Lausanne) 4:159
Hope, Chelsea; Emmerich, Philip B; Papadas, Athanasios et al. (2017) Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer. J Immunol 199:1933-1941

Showing the most recent 10 out of 95 publications